Designs for Health Mito-NR - Nicotinamide Riboside (NAD Supplement) with COQ10 + Trans Geranylgeraniol - NR + GG Supplement for Mitochondrial Cell Health Support (60 Capsules)

I'm into Nootropics and brain function/health. I have dementia in my family history. Although my genes seem to be okay, and I do have a gene that seems to be present in people who do not develop dementia even if they have many genes that are pro dementia.... I am still dealing with regular brain fog, and daily functionality challenges. We are all expected to be so fast these days and we also have to achieve this level of amazing with fewer toxins. I do not like caffeine. So, I have started using NMN and other supplement blends that can and often do show a result in as little as a few days and then some within an hour of taking it. This product is more of a three to five day timeline, to notice a shift. If you are not doing things that show an obvious measure of your mental fitness on a given day, then you'll likely not notice anything. Likewise, if you are really bright and high functioning most of the time, you probably will not have a noticeable shift. I do have challenges, mostly due to an issue with frequent migraines and the brain fade in the wake of those things. This is not the only product I use to help me with my brain processing quality, so it can take a while for me to evaluate new supplements, away from other similar products. This product, like others from this company/brand, is a functional quality.I do what I can to boost my brain function, and since youtube started promoting NAD+ and NMN, for anti aging and brain health, I have paid attention. It is SUPER expensive, but I am hoping that the prices come down. Something about this brand, it is being promoted by doctors who are a part of fullscript, so you can save that way. My doctor subscribes and prescribes through fullscript and I found out about this brand through my doctor. So far the probiotic, Pro Biospore, and a few other products have been obviously and specifically effective for me and my health concerns/challenges. That is the only reason why I noticed this product and decided to try it. As a value online, this price is actually competitive for what is listed on the label. Hopefully as we move along, prices should level out and be more kind to our wallets. It's crazy how expensive things are. This combination of supplements is still relatively new on the market and it is super pricey.5 stars

This gave me severe stomach cramps, almost to where I thought I needed to go to the hospital. I’m not sure what was in it but something in it had this effect on me I had to discontinue taking it.

DFH is a premium-priced brand which rests on name alone for quality assurance. The claim to use Niagen in this product which, taken at face value, offers some early evidence of ability to improve NAD levels. For what that is worth. We do know that NAD drops off with aging, likely related to increased CD38 activity. Whether supplementing to increase NAD levels is of any value really still remains yet undetermined, but mechanistically it would make sense. This appears to be true in rodent models, but not clear yet in humans. Hence, based on that assumption Niagen is a reasonable choice to achieve that goal. Ubiquinone also decreases with age but, again, supplementing has really no proven benefit that I am aware of unless you are on a statin (and if you are, why???). The final ingredient, Geranylgeraniol GG, I have no idea about. I am not familiar with it and have seen no evidence of any benefit.For all of that you pay $88 for a month supply. I get these free as a trial, but I would not pay that much for something with such little evidence of benefit. I do like to experiment, though. Such experimentation will only be useful for subjective, short-term effects, which is unlikely for a product such as this. Anyway, with all that said, you still really do not know what is actually in any supplement unless there is verified third party testing, and DFH never seems to offer that one simple quality assurance. For this reason I can never give their products greater than 4 stars. I would always go with a product that has been verified. There is simply too much shenanigans in the nutraceutical industry.Final word - while human benefit remains unclear, safety is pretty well established for niagen and ubiquinol. Not sure about the Geranylgeraniol GG. HOWEVER, none of the testing included pregnant women. I saw the pregnant lady review and I am concerned about that. In that situation there is no safety data and you are really flying on faith. Also during reproductive age you likely would not need anything to boost your NAD. Just my public service announcement.

I normally consume 200-400mg CoQ10 and 125-500mg NMN daily and was curious to see if I could tell a difference switching from NMN to Niagen and adding on Trans-Geranylgeraniol (which I've had on my back burner for awhile). GG helps CoQ10 work better and fights sarcopenia (it also works great in conjunction with statins, which I'm not on). CoQ10 is not only helpful for the elderly or those with heart disease, but also neurological disorders, diabetes, and hypothyroidism.I have the neurological disorder ME/cfs, which means that I have a problem with my mitochondrial energy. I am definitely noticing a difference so even though this product is very pricey, and I wish it were a little cheaper, I think I will probably continue with both this and their CellGuard-NR as I was already taking most of these substances separately - it's about the same amount of pills with more in it and only a little more expensive. Since I've had ME for over a decade and also not new to most of these supplements, I do not feel that this is a placebo effect, although there is always the risk my body will develop a tolerance over time and be less effective that way. The amount of Niagen in this is a bit low, which is another reason I might want to stack on another supplement with Niagen (but individual dosage goals will vary with both Niagen and NMN). I have not noticed any negative side effects and feel more energetic in the daytime but not any sleeping problems.

Supplement arrived with broken seal and cap.