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Prasugrel is novel thienopyridine antiplatelet prodrug that is metabolized to the thiol-containing active metabolite R-138727,which binds to and irreversibly inhibits the platelet P2Y12ADP receptor. Prasugrel is metabolized by the liver-Â and intestinal-dominant carboxylesterases CE1 and CE2 to give a mixture of four enantiomers that inhibit platelet aggregation...
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