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E45 Itch Relief Cream is a dermatologist-tested, perfume-free treatment formulated with 5% urea and 3% lauromacrogols to provide instant and lasting relief from itching and irritation caused by eczema, dermatitis, and dry skin. Suitable for all ages including infants over 1 month, this 500g cream delivers 24-hour hydration and has been a trusted skincare staple for over 60 years.





| ASIN | B001EJOHUU |
| ASIN | B001EJOHUU |
| Active Ingredients | urea |
| Age Range Description | Adult |
| Benefits | Soothing |
| Best Sellers Rank | 483 in Health & Personal Care ( See Top 100 in Health & Personal Care ) 4 in Itching & Rash Treatments |
| Brand Name | E45 |
| Container Type | Bottle |
| Country as Labeled | United Kingdom |
| Customer Reviews | 4.6 4.6 out of 5 stars (3,261) |
| Customer reviews | 4.6 4.6 out of 5 stars (3,261) |
| Is discontinued by manufacturer | No |
| Item Dimensions | 50 x 50 x 240 millimetres |
| Item Form | Cream |
| Item Type Name | E45 Dermatological Itch Relief Cream 500g |
| Item Volume | 500 Millilitres |
| Item Weight | 550 Grams |
| Item model number | 348713 |
| Manufacturer | E45 |
| Manufacturer | E45 |
| Manufacturer Part Number | 285-3331 |
| Material Type Free | Paraben Free |
| Model Name | E45 Dermatological Itch Relief Cream, Moisturising Dual Action Treatment for Itchy and Irritated Skin, 500g |
| Model Number | 348713 |
| Number of Items | 1 |
| Other Special Features of the Product | Travel Size |
| Product Dimensions | 5 x 5 x 24 cm; 550 g |
| Recommended Uses For Product | Eczema |
| Scent Name | Unscented |
| Skin Care Application Time | Anytime |
| Skin Type | All |
| Special Ingredients | Lauromacrogols 3.0%w/w, Urea 5.0%w/w |
| Specific Uses For Product | Eczema |
| Sun Protection | SPF 50 Sun Protection Factor (SPF) |
| Target Use Body Part | Whole Body |
| Unit Count | 500.0 gram |
D**P
Works well
Really works well make sure you choose the correct product, cream not the cheaper lotion which is a good moisturiser but does nothing for itchy backs. Good dispenser
A**R
works well
working so far
G**Y
OMG THIS WORKED ITS A MIRACLE
Well I didnโt hold out much hope as nothing so far has taken away my Itching. But OMG as soon as it was applied. It felt cold which was amazing in itself. But the Itch was gone. Iโm so happy. I am totally bedbound. I canโt even move by myself. So when I get an itch which I do all of the time. Itโs horrible as I canโt reach it and also as my skin is so fragile. Scratching just opens it all up. I canโt sleep at night because of the itching. I canโt describe the feeling if not itching. Itโs amazing. Just give it a go. What gave you got to lose. And yes it might be a tad expensive. But a little goes along way. And taking away the itching. I would have paid anything. So to me this is a small price to pay.
M**E
It's good cream
This cream should have been delivered today now told it won't be delivered till the 15th no reason given but I'm t0ld can not cancel why
R**N
always clean area before use to make the cream to do its job and pure bliss no more itching
absorption ease of use
M**E
Value for money ++
Fantastic deal.
D**N
best for itchy skin
orddred and delivered same day absolutely works on itchy skin
C**S
E45 Itch Cream
Great product ordered and delivered within advised timeframe.
B**Y
Works great
W**S
HEAVEN in a bottle ๐๐ฝ๐๐ฝ๐๐ฝ๐๐ฝ I have been suffering with eczema on both of my hands, of all places since June 2025 and I have literally tried EVERYTHING.. nothing works. Not even the prescribed medication. Long story short I read a post about E45 on Facebook about the same condition I have. Extreme itching, eczema. Yada Yada.. it hasnโt even been 24 hours. I could cry ๐ญ I know itโs pricey but itโs worth it!
S**L
Great product and good review.
H**A
Bought this for my father in law bc he was itching like crazy!! I think he has excema but won't go get it checked out. He would itch until the point of bleeding. So a friend told me about this cream that helped her. I ordered it and low and behold it worked! He loves it so much the bottle is almost empty and I got it like 6 months ago. It was very effective for him and he stopped itching when he put it on. Will be buying again for him and also no more bleeding thank god!
P**S
I've developed a mild eczema on my hands, arms and ankles and got a steroid cream prescription. When traveling home from England, Heathrow confiscated my steroid cream from my purse and forced me to put in my luggage even though a prescription label was clearly affixed to the tube. To try and cope on the flight, I bought a small tube of E45 Itch Relief at the airport drugstore, and was surprised at how it calmed down the red patches on my hands. I used up the tube at work over several months, and amazingly have now got down to using the steroid cream maybe once a month or so with a bad flare up. After reading how steroid cream can cause long term serious side effects, I combine this with a heavy Eucerin emollient on top at night. When the tube ran out, I bought this big 500g jar. I'm terrified to be without it as it has really reduced my use of the steroid cream.
Trustpilot
3 weeks ago
1 week ago