Overnight Calming Serum for Flaky, Itchy Scalp & Skin 8oz | Steroid-free. Clinically tested. Reduce visible flaking, soothe itch & irritation for seborrheic dermatitis-prone skin types

It’s been 30 days, and I can finally say it: this serum is a game-changer. I have no flakes, no itching, and no redness anywhere on my scalp or hairline. My hair even feels healthier and easier to manage. I’ve been using the serum twice a week along with washing my hair with Nizoral shampoo, and I’m honestly blown away by the results. No side effects, no irritation. Just calm, clear skin. I also mixed in a little MCT and essential oils early on to save a bit, and that first wash cleared out a ton of buildup. It hasn’t come back at all. Not even one flake! I noticed results after the first wash, which completely surprised me. I’ve had dandruff since I was a teenager (I’m 46 now), and this is the first routine that’s actually worked. The serum is lightweight, non-greasy, and absorbs quickly. It has a mild scent that isn’t overpowering. The dropper makes it easy to apply the right amount directly to the scalp without making a mess. It’s not the cheapest product out there, but for what it’s done for my scalp, it’s worth every penny. If you’re dealing with Seborrheic Dermatitis or stubborn dandruff, don’t wait. Try this. I’ll keep buying it for as long as it works, and honestly, I wish I had found it sooner. This deserves 10 stars!!

Literally magic in a bottle. I recently found out that constant itching I have always had and build up of flakes is because I have seborrheic derm in which I have been trying the past month to calm down with nizoral. It’s made it more bearable but my hair still got smelly, itchy and heavy flakes two days after I washed. Then I asked chat gpt if there is a serum out there that could calm this down for good and basically extend my washes so I don’t have to keep washing my thick hair every other day religiously and it led me to dermazen. Within literally one second of applying dermazen, the itching stopped, it works so well. My day 3 scalp felt as calm as if I just came out of the shower. I am excited to see the long term effects of this product but I will say, even though it’s a hefty price, it’s worth every penny. I am so happy I finally found something that works for me. For those wondering about the texture of the serum, too me it feels more watery than sticky. It has a faint smell of tea tree oil but its not strong enough to make your whole scalp smell like it. I am using it in between wash days as a leave in or overnight before a wash but I am still finding out what works best for me.

I'm on my second bottle and watching this ad again is making me tear up. My scalp suffered daily for over FIFTEEN YEARS. It started out of nowhere, and dermatologists told me the exact same thing - that "it just happens" to some people and they didn't really have a good solution. I've determined through my own research the cause of my issue is malassezia. I have tried anything I could find, and this has been the only thing that not only helped, but I would even go as far to say that it cured my scalp issue. I actually haven't quite finished my first bottle, and only have it on hand now to use if my scalp starts to feel a little irritated. Before, my scalp would flare up, flake, and scab every single day. Now I can't remember the last time I had flakes, or even a flare up. I cannot fathom why this treatment has not been adopted as a dermatologist backed treatment for malassezia. If you are thinking about trying this, just do it - this is the one.

I am a Physician with seborrheic dermatitis. The ads and comments and claims of this product to treat same sounded wonderful. Well. I am here to tell you this product is close to a scam and worthless. This liquid caused my face and neck to flare horribly and turn my skin badly red and made the itching much worse. In my professional opinion this product is snake oil. Purchase if you want to waste your money. Would have rated it one star if the system allowed. Stay. away. You were warned.

The first 4 pictures were taken on 2/20/26 and the last 2 were taken today 5/18/26! I was so scared that I wouldn’t be able to ever put my hair up again. This flare up happened through my postpartum journey due to stress. I went to urgent care and they prescribed me a steroid but I didn’t want to rely on it so I did my research looking for other alternatives. After finding this brand and seeing that reviews varied I thought “At this point, what do I have to loose?” I never would have thought that it would be the most life changing decision I could have made! To give others an idea of my routine I use their seborrheic serum an hour before taking a shower. I pour from the bottle onto my scalp, rubbing it into my scalp with my fingers, and let it sit. Initially, it feels like a burning sensation but quickly calms down. I use Nizoral for shampoo and conditioner. I get a good lather of shampoo and use a scalp massager to help with the flakes then let it sit for a couple minutes before rinsing. Conditioner as normal. After getting out, I run Dermazen’s MCT scalp moisturizer on my fingers with wet hair and massage through the same area. The moisturizer can leave my hair a bit greasy that’s why I don’t pour it directly from the bottle like the serum. Lastly, I use my hair dryer on cool air to help dry it down then go on about my day without a care! I go about 2-3 days between washes. With all these things combined it helped me regain the health of my scalp and my confidence back! I’m not worried about the fear of someone staring at the back of my head in disgust. Thank you Dermazen!

In 2020 I was out hiking in northern California and managed to get poison oak all over my face. I was prescribed a steroid that absolutely destroyed the apparently delicate balance of yeast and bacteria that lives on all our faces, and since then, I've been battling "fungal acne" (actually called malassezia folliculitis, as it's more of a yeast overgrowth than acne). Unfortunately, once malassezia gets bad enough it creates a defense barrier called a "biofilm"on top of itself, making it difficult for anti-fungal treatments to reach. I found out about this digging deep into the archives of Simple Skin Care Science, a website I *highly* recommend for anyone struggling with skin issues, or looking to have nicer skin in general. The author and owner of the website suggests checking any products you buy for fungus-feeding ingredients on the website "Sezia", where you can enter the ingredients list, and it will tell you if any ingredients are likely to worsen the yeast infection. On the Sezia website, I found a page called "BEST SKINCARE FOR MALASSEZIA" and on that page, Dermazen was recommended as a product to help fight the biofilm. Well, I can confirm - Dermazen most definitely destroyed the biofilm on my face. It did not eradicate the malassezia, but by dissolving the biofilm, it made it possible for some of the antifungals to finally penetrate and reduce some of the yeast overgrowth. It also HYDRATES incredibly well - if I want my skin to look plump and beautiful, I can put a few drops of this on before bed and my skin looks incredible in the morning. I can't express how grateful I am for that, as my fungal infection is still very much active (the longer you have a fungal infection, your body develops resistance to antifungals, which is the stage I'm at) and as a result, I can't risk wearing makeup which would feed the yeast further. But truly, my skin has never looked better, unless you look really, really close - and then you can see the fungal infection which up close, looks like my face is covered in tiny blackheads/clogged pores. This product gave me hope, and although I'm still struggling to battle the yeast, the hydration it provides has allowed me to start using Differin, an extremely drying product that my rosacea normally can't tolerate. Every ingredient in this formula is excellent - I've used most of them separately (ie. niacinamide, HLA) or in other formulas, and I can say the team here has done something really special. I'm bummed that it's been going up in price because I need this for medical reasons, and haven't found anything as good. My only bit of feedback is I'd prefer a dropper - the way the top is, you have to dump the bottle upside down over your face, which is a bit awkward and it's hard to keep it from rolling off your face, as one hand is holding the bottle. I put mine in a smaller bottle with a dropper, which makes it easier to control how much comes out. Finally, I have to add - the packaging (aside from the top) is a 10/10 for me. It's the nicest label I've seen on a skincare product. Minimalist, spa-like and makes my bathroom look more peaceful. The print of the label is high-quality and even has sparkles in it.

I rarely write reviews, but this actually helped completely clear up scalp issues that I had had for over a year. One dermatologist said it was seborrheic dermatitis, the other said it was scalp psoriasis. Both said that it was not curable and that I would be battling it for years. After 2 months of using this, the dermazen shampoo and conditioner (relatively consistently, and a scalp scrub from another company) plus Broc Shot supplements. It is completely gone. Like gone. I will still continue to use the shampoo and conditioner, but my dermatologist says that it is cleared up. I really thought I was buying snake oil, but it somehow actually works. I was not given this for free and am not an influencer. I am just a very relieved mom who was over making time for dermatology appointments.

I haven’t used this product long enough to fairly review its effectiveness, so I’ll update in a few weeks on that. The most important feedback/info I would offer at this moment is that this isn’t a serum in the way I have always understood the word, and I’ve used lots of skincare products over the years… it’s a toner, 100%. A serum has (light) weight to it and remains on the skin until it soaks in, but this product is like witch hazel or tea tree oil toner in that it stings when applied and immediately evaporates. That doesn’t mean it’s a bad product, of course. But being labeled a serum misrepresents what it actually is. It most definitely isn’t moisturizing, at least for my skin, but if it helps when I have flare ups, I’ll be happy to use it like a toner!