Is there a scientific study that I can read that will back up these claims?

Absolutely, there are studies! There are enough that I need to ask you to be more precise in what you want to know. Which ingredient are you interested in, for what population, and concerning what symptoms? Your local library may be able to help you access research databases that will allow you to search to your heart's content. State libraries may be used by any taxpayer, and some medical schools will allow community members a day pass. Here is a little taste, notice how long this research has been going on: 1) Weisberg, I., Tran, P., Christensen, B., Sibani, S., & Rozen, R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular genetics and metabolism, 64(3), 169-172.2) Grandone, E., Margaglione, M., Colaizzo, D., Cappucci, G., Paladini, D., Martinelli, P., ... & Di Minno, G. (1997). Factor V Leiden, C> T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thrombosis and haemostasis, 77(6), 1052-1054.3) (The title for this one is unfortunate, it is a randomized, controlled clinical study which is the gold standard, and it found the reduced B vitamins to work to alleviate symptoms of major depression as well as homocystine levels. 4) Sontag, J.-M., Wasek, B., Taleski, G., Smith, J., Arning, E., Sontag, E., & Bottiglieri, T. (2014). Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in Aging Neuroscience, 6, 214. http://doi.org/10.3389/fnagi.2014.00214There is your taste! There is also research showing lack of/poor sperm count in males with homozygous A1298C variant of MTHFR, higher risks of pre-eclampsia in pregnant women, etc., etc., At this point, I'm surprised that routine screening has not yet become a standard of care. I hope that the variation of research articles here has helped you to understand why a more precise question is needed for a direct answer. No single study will do it (and never does). How about 2 decades of research? :)

There seems to be some confusion about the difference between Methyl-Guard and Methyl-Guard PLUS, which costs twice as much as the regular Methyl-Guard listed on this page.Jana B.'s answers above seem to list the ingredients of the plus version, although the amounts appear to match that of the regular version. (?)This version does NOT have Riboflavin (B2) (Riboflavin 5'-Phosphate Sodium). In addition to B2, the plus version also claims to have more of all of the ingredients listed below.I have never purchased MG-Plus but I have a bottle of the regular Methyl-Guard in front of me.Here are the ingredients as listed:3 capsules contain:Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg 1,020% DVFolate (as L-5 Methyltetrahydrofolate from L-5 Methyltetrahydrofolic Acid, Glucosamine Salt) 1.2 mg 300% DVVitamin B12 (as Methylcobalamin) 1.2 mg 20,000% DVBetaine Anhydrous (Trimethylglycine) 1.8 g *DV not establishedOther Ingredients:Hypromellose (derived from cellulose) capsuleCalciumCitrateLaurate (sic)Silicon DioxideSuggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner. (Personally, I only take 3 a day, not 6)

This states 180 capsules???

Thorne Research - Methyl-Guard comes in a 180 capsule sized bottle.

What is the difference between the old label and the new label?

Also some of the amounts are different. Old methyl guard: Three Capsules Contain: Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg. Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE Vitamin B12 (as Methylcobalamin) 1.2 mg. Betaine Anhydrous (Trimethylglycine) 1.8 g. New Methyl guard Plus: Three Capsules Contain: Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE Vitamin B12 (as Methylcobalamin) 3 mg Betaine Anhydrous (Trimethylglycine) 1.8 g This is from the thorne research website. I love the old one (helps with depression) but the plus gives me a migraine.

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Reviews

A**L

Quality product that really makes a difference

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

4.08.2025

A**.

So far, so good!

I am not a medical professional. I find this product to be of great quality. It helps me to function on tired mornings, and seems to be working when I take it as part of my morning supplement regimen. I have had no issues with the taste nor the smell. Careful not to overdo it with this and other products that contain redundant ingredients. Always read your labels carefully and cross check for redundancies. Happy with this thus far.

20.08.2025

M**G

This is amazing

I never write reviews for supplements. I started taking this because I started using an NAD+ patch. They recommend taking a menthylation supplement. (I'd never even heard of it). I took 3 tablets in the morning before my patch. Within 30 or 45 minutes, I immediately felt great, energetic. I can't even explain it. I hadn't changed anything else. I thought , "no way". I decided to take it the next day as well. Same thing! More energy, clear head, sort of, maybe happier. I can't believe. I've never a supplement do that for me. I have taken everything. I am menopausal and take HT (Evamist and progesterone 200mg). But this is the first thing I have taken to truly have an immediate impact. I can't say you will have the same results. Like I mentioned, I bought for a completely different reason. I'm thrilled with how it makes me feel. It's been 4 days now. It's wonderful.

9.08.2024

C**R

Proven efficacy

Im not much for reviews but this is awesome! I had my homocysteine up at 12.97 and after a few months of this at my last draw it was down to 7.49!! Definitely works!! Proven!!

3.11.2025

R**I

Methylated folate

A key product for anyone with the MTHFR Gene. Really, the only thing you need (unless you are homozygous (have both genes).

9.11.2025

H**.

Good quality, supports methylation cycle well.

Since I have a double mutation on a gene that is important for the methylation cycle, I need to take this every day now. I feel the difference immediately when I miss a few days.

25.08.2025

T**S

Great for vitamin B deficiencies

I was having terrible muscle pains and went to my doctor. Blood work was done and it was found that I was severely deficient in the B vitamins (malabsorption issues in my digestive system). I did the injection of B vitamins in the doctor's office but needed to go on supplements to correct the deficiency long-term. I bought these and take two tablets, three times a day. I am now in to my second refill and it is four months later. The muscle pain has gone away, so has the numbness in my feet. I also feel like I have more energy.

7.10.2024

H**Z

Muy bien

30.08.2025

C**Y

Excellent product for MTHFR genetic disorder

11.09.2025

ASIN	B0012FJVA2
ASIN	B0012FJVA2
Age Range Description	Adult
Allergen Information	Dairy Free, Fish Free, Shellfish Free, Soy Free
Best Sellers Rank	#17,604 in Health & Household ( See Top 100 in Health & Household ) #495 in Blended Vitamin & Mineral Supplements #1,655 in Diet & Sports Nutrition
Brand Name	THORNE
Container Type	Bottle
Customer Reviews	4.7 4.7 out of 5 stars (1,080)
Date First Available	April 11, 2005
Diet Type	Gluten Free
Dosage Form	Capsule
Flavor	Unflavored
Global Trade Identification Number	00693749787037
Is Discontinued By Manufacturer	No
Item Dimensions	2.89 x 2.89 x 5.22 inches
Item Form	Capsule
Item Weight	180 Milligrams
Manufacturer	Thorne Research
Manufacturer	Thorne Research
Model Name	e Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules
Number of Items	1
Product Benefits	Bone Health
Product Dimensions	2.89 x 2.89 x 5.22 inches; 0.01 ounces
Specific Uses For Product	Brain, Heart
UPC	693749787037 885335121343 884733360033 885100656025 881619227596
Unit Count	180.00 Count

Methyl-Guard - Supports Methylation for Healthy Heart, Blood Vessels, Brain & Bones* - Vitamins B6 & B12, Folate (5-MTHF) & Betaine - Gluten, Dairy & Soy-Free - 180 Capsules

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