I'm looking at the photos, and if the large top opening isn't covered, how do the treats stay inside?

You can also fill it with treats, wet food, peanut butter, etc and freeze before offering. Otherwise, get the large and the small, fill the large, and attach them as shown in the picture to make a treat dispenser.

Is this made of plastic, rubber, or silicone?

Per the description on the page it says, “Zogoflex® is a proprietary blend of plastics; it is NOT rubber. ” BUT, earlier in the description it says “Rubber” prongs. They definitely need to clear this up.

Has anyone used this with a large breed flat-faced dog like a boxer?can they fit their mouth or tongue in to get the stuff out?

I have a Weimaraner, and although not flat-faced, after watching him with this toy, I would say your pup would find a way. That's what keeps them busy. I leave a jar of peanut butter in the fridge to get somewhat hard, then smear some on the inside (near the top and bottom) instead of putting a hard treat in the toy. It keeps him very busy and he could care less that I was leaving : )

I have a Newfoundland will the large be large enough?

I don't think it will be big enough for your dog. My 21 lb. dog has a large and my 3 1/2 lb. chihuahua has a small. I think West Paw makes other treat dispensing toys that are bigger - check on their website - www.westpaw.com.

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Description

About this item
Zogoflex is an exclusive material that makes fetch, tug-o-war, and chew therapy more fun — it’s easy on doggie mouths, stretches (without stretching out) and sports an unstoppable bounce — all while staying tenaciously tough. For dogs who love to swim (or just need a distraction in the bathtub), Zogoflex stays afloat.
Toppl is a puzzle dog toy that traps treats with its inner ridges and tips over to keep dogs entertained and challenged, interlock the two sizes (sold separately) to make playtime even more fun
It’s easy to sanitize Zogoflex toys at home — just pop it on the top shelf of your dishwasher.
Traps treats with its inner ridges and tips over to keep dogs entertained and challenged.

West PawsDesign Zogoflex Toppl, Orange, S

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