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🐾 Protect your big pup like a pro — no pests, no worries!
K9 Advantix II XL is a vet-recommended, fragrance-free topical treatment designed for dogs over 55 lbs. It kills and repels fleas, ticks, mosquitoes, biting flies, and lice on contact, eliminating fleas within 12 hours. Waterproof after 24 hours, this easy-to-apply monthly treatment requires no prescription and comes in convenient 6-month supply packs, ensuring your dog stays protected indoors and outdoors with minimal effort.














| ASIN | B004QRJJ0K |
| Active Ingredients | Imidacloprid, Permethrin, Pyriproxyfen |
| Age Range Description | 7 weeks and older |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #198 in Pet Supplies ( See Top 100 in Pet Supplies ) #2 in Dog Flea Drops |
| Brand | K9 Advantix |
| Brand Name | K9 Advantix |
| Customer Reviews | 4.5 out of 5 stars 49,335 Reviews |
| Global Trade Identification Number | 00724089204295 |
| Item Form | Topical |
| Item Type Name | Topical |
| Item Volume | 24 ml |
| Item Weight | 1.6 ounces |
| Manufacturer | Elanco US Inc |
| Manufacturer Part Number | 86315068 |
| Model Number | 81520429 |
| Scent | Unscented |
| Scent Name | Unscented |
| Target Species | Dog |
| UPC | 024089616501 724089204295 |
| Unit Count | 6 Count |
| Volume | 24 ml |
S**J
Reliable product - highly recommend - works !!!
Always use this brand flea preventative . It kills many critters trying to annoy and hurt my pups . I want my fur covers kids just as safe as my flesh covered kids ;) The product is the best for fleas ticks and mosquitos . And in this heat and lack of freezing temps , ticks and rad and skeeters are running ramped out there . The size depends on your dog’s weight please read their chart within the ad . Then there are single dose , 2 pack, 3 pack and 6 packs available . It is to be used once a month . Imagine this .. the liquid seeps into your pets skin and spreads around via the oil in the skin . It gives them complete protection as far as coverage . There is not a spot a flea can bite them and survive . Most fleas and ticks will be repelled by the scent that we cannot smell once it is “ in/ on “ them . It uses your pets natural body chemistry to help it work better . You should wait at least 2 days after giving a bath to use flea protection like this . The pet needs to replenish the oils that a bath(shampoos) dries out . Then it will work better . Do not use on wet skin either . It is best to separate the hairs on your let until you see skin ( best spot usually base of back of neck where they cannot reach or lick it ) Then place the vial to the skin and squeeze gently . Be aware of your eyes !! If you have larger dogs there is more in the vial so I will do one spot then spread hairs next to that spot and apply rest in same area but different spot This way it all sinks in and it won’t run onto the hair and clump up . If it does leave it for now let it all dry after a day just brush the spot to eliminate a tangle . I have been using this product for as long as I can remember and the animal hospital I worked at recommend this product as well . It will treat more than frontline plus will . I feel better also. My dogs don’t itch all the time . There have been no reactions or issues from this product on their skin . IF ingested by pet they need to be taken to ER right away . And if ingested by humans as well-ER move it move it move it !!! Poisonous if ingested or gets into eyes of you or pet. I like the snap open vial better than the get scissors and cut open vial Doing that can cause a squirt . I always look other way when opening these and never near pets face . Always wash hands with damp after applying to pet asap. A very durable reliable product for your and your babies . A size for every pet and peace of mind for every owner / parent
R**N
My go to for Flea and tick prevention.
After trying several different flea and tick treatments over the years, K9 Advantix has consistently been one of the most effective options for my dog. Application is quick and straightforward, and within a short time I noticed a significant reduction in fleas. Living in an area where ticks are common, it’s reassuring to know my dog has reliable protection during walks, hikes, and time spent outdoors. One thing I appreciate is that it doesn’t leave a heavy, greasy residue once it’s had time to dry, and my dog hasn’t shown any signs of irritation after application. Following the recommended dosing schedule has kept the protection consistent month after month. The peace of mind alone makes it worth the investment. Keeping fleas and ticks under control is much easier than dealing with an infestation, and this product has helped do exactly that. Based on my experience, K9 Advantix is a dependable choice for pet owners looking for effective, easy-to-use flea and tick protection.
Y**N
It works and works fantastically
I've been using K9 Advantix (I and II), and I've never had to worry about ticks, fleas or mosquitos, and I live out in the woods in a state that has these critters *everywhere*. My dogs walk all around in the fenced off area of ~4 acres, which I keep mowed to 3.5 inches and only a few trees in the main backyard but a .5 acre cedar grove in the front of the house. Cedar keeps the climbing bugs at bay well enough, but walking the fence line in the back and around the 100 yd x 50 yd pond and I have to check for ticks on me when I get in. The dogs will have a couple on them, but they never get the chance to dig in, so leaving them outside a lot of the day and night doesn't concern me. When they're inside, wherever they sit or lay, they're leaving an extremely small bit of this stuff on the material that also kills the crawling critters. The pond, naturally has mosquitos, but they don't hardly land on the dogs...unfortunately they DO land on me. As I said, I've used this stuff for decades on my dogs and because of it they're not uncomfortable from biting insects and the mosquitos pretty much leave them alone or die after lighting on them and don't infect them with heartworms. Also, this is like water, so when putting it on the dogs you need to put it in several spots on their back for it to work best. Because it's a water-type stuff, no more messy, gunky oil-based junk to get all over your hands or places they lie or collect dust/dirt/etc. Overall this can't be beat since it covers pretty much any critters that would love to make a home on your dog.
J**H
The GOOD and BAD.. Kills EVERYTHING
So this stuff kills and prevents it ALL! That's the good part! The bad is... it kills and prevents it all... SO if I continually put this on my dog... onto his skin.. down his back... and your skin is the largest organ that absorbs it... This cannot be good for my dog long term. I used to do this when flea/tick season was in high gear in my area (google flea/tick season for your state) and then stop in the winter months. Then I slowly just tapered off and stopped using this all together. It works and works well. My dog has no issue with it at all. The months I had put this on him, no flea or tick or mosquito in sight. It does spread into his long fur and takes a bit to dry/absorb like a day or two so that can be messy. You can't really pet him down his back at that time. You're not supposed to bathe them before or right after application. He never had any skin rashes or negative side effects from it. That being said, I personally decided to stop using it monthly. I don't take him to tick heavy areas like woods and if I do, I always, always, always do a thorough tick check on him. It's tedious, he has long, thick hair (golden retriever) but worth it 1000%. Of all the things in life I will mess around with, ticks and the diseases they carry (esp. lyme) are not one of them. Fleas, I will treat with capstar if need be but not really any fleas get on him. That being said I still purchase and keep this stuff around, WHY? because it kills everything. It's amazing to have on hand for emergencies, mainly like when a tick ATTACHES to him and I'm so scared if I pull it off wrong, it's head will still be in his skin (this is bad because it can still transmit diseases this way). SO when that happens, I get this out, put a generous DROP onto the tick and let it do it's magic. Let all those chemicals and pesticides and whatever kill that TICK at least paralyze it so it cannot bite and hold onto my dog's skin anymore. This takes, well I give it 30 seconds but usually a min or so to be safe. Then, I do what they say to do, grab the tick with tweezers and gently twist and off it comes head and all. I then, because I hate them so much (the only thing worse and scarier than spiders are ticks) burn them with a lighter. I show them NO mercy. Anyways, this product works, it doesn't have any bad effects on my dog, BUT I don't use it regularly anymore because I think it can be a lot on my dog's body/immune system. I DO keep it around though for emergencies that can and do crop up. That's part of life and owning a dog. So would I repurchase, YES, would I recommend? Yes. Just not all the time, but to have on hand. I'm not saying eliminate all chemicals and never use them, I just reduce WHEN I can.
A**E
Works great awesome I definitely suggested
UPDATE I don’t know what y’all all your people take your dogs to the vets instead of showing them online here that they can’t walk. The fur is falling out of the bleeding. That’s ridiculous. Take your dog to the friggin neck. Let the vet determine the cause exactly and then if it’s in clause because of this then Put a negative and state the fact that you took him to a vet and the vet did test and it was the closet because I’ve been using this product for 25 years on my dogs back then and my new dogs now my dogs I had 16 years ago dogs I had 10 years ago dogs I had 13 years ago my 16 1/2 year old cocker spaniel has had this from the day he could actually have this And I have never had a problem with that on any of my dogs especially him you know it got rid of the fleas and I noticed a few texts very easy to get off compared when I didn’t use it like if I skipped a couple of months and they had a dick and I was like oh my God and then I would try to get it off and it was a hassle. I mean, it did not pull up. Come out whatever And so I put them back on this every month originally and if they get a tick and I see it. I just need tweezers and it just pops right off no eggs inside nothing no problem with the weather did not cause any of my dogs ever itch or lose hair so I think you people have an undergoing problem with your dog that you did not address Prior to use this. Yes, I’m gonna blame you. Yes I’m blaming all you that people that has undermining problems with their dog and you don’t take them to the vet and you add this product on top of them. Yes, it probably will do something like that. SO I REPEAT, TAKE YOUR DOG TO THE GD VETERINARIAN PROFESSIONAL LET THE PROFESSIONAL DO THEIR WORK !!!! Oh, I also have one dog right now. I have three of them English mastiff and I have one of them that sits at my back gate in the dirt never has fleas never has sticks never has any. He lays in the dirt 185 pound and his head I can look it out right now his head is in it. His whole body lengthwise is in it and I swear he digs holes just you know it makes it cool.. and there’s a picture of him laying at the fence in the dirt. He loves it. I check them every day. Nobody has fleas. Nobody has anything so you people are doing something wrong. I’m gonna blame all of you. They have a problem and I’ll say it again again again they have underlining problem TAKE THEM TO THE VET VETERINARIAN HAVE THE VET, VETERINARIAN, TECHNICIAN, AND DOCTOR EXAMINE THE DOG TAKE SKIN GRAPHS WHATEVER THE BEST HAS TO DO. DON’T BLAME THE PRODUCT UNLESS YOU DID THAT AND IF YOU DID IT AND THEN DOCTOR RUNS TEXT AND SAID YES, IT WAS CAUSED BY THAT PRODUCT. WELL HENCE THERE YOU GO AND IT’S THE PRODUCT FAULT BUT A 99.999% IT’S NOT THE PRODUCT. Started having dogs when we first got married we have we had seven English mastiffs yeah it’s addicting and they had puppies and everything so anyways I’ve been using this on my dogs from year 2000 and I use them before that on my other dog so I’ve always used it really and I love it. I mean, I swear by it this stuff is great. My dogs do not get flea or I mean I have to put a spray on them to detail the mosquitoes, but don’t see my bugs biting them. It’s pricey, but it’s worth it. You don’t wanna have your dogs get Lyme disease or you know from ticks, I really suggest this. No bother my dog knock on wood you know in the other thing is I don’t use this year around. I only use it from spring until after fall. I don’t feel I really needed in the winter time. It’s too cold outside for anything to live so I’m up Northeast And I don’t seem to have any problem and they’re not using it as soon as spring hits that’s that boom they’re on it.
Y**N
The safest and most effective tick protection - ticks fall off just from touching the fur
I brought my dog to West Virginia, and thank God for Advantix II — because I’ve been finding half-dead ticks every single day (no joke) in places where she sleeps or rests. At first, I was confused. I thought "repels ticks" meant it would work like bug spray does for mosquitoes, keeping them away completely. But after looking into the active ingredient, permethrin, I realized that in this case, “repel” means: once a tick touches the treated fur, it becomes so irritated or neurologically impaired that it can’t bite, can’t hang on, and eventually just falls off and dies. That’s still so much better than PetArmor, Frontline, or any of the oral preventatives (like Simparica or NexGard), which require the tick to bite the dog before it dies. No thanks. Every tick I’ve found so far had already dropped off my dog before it had a chance to bite her and feed — exactly what you want in a tick-heavy area. I’ve also tried Wondercide (cedar oil). It works okay for fleas, but it’s just not effective for ticks, especially not in the long term. Its protection wears off after 2–4 hours. I learned the hard way — my dog caught Lyme disease, developed joint pain and a limp. Thankfully, doxycycline helped and she’s okay now, but it required a full 28-day antibiotic course. I would never use oral flea/tick medications. Just ask around — you’ll hear plenty of stories about dogs having seizures after taking them. For me, that risk isn’t worth it. If you have a cat at home, unfortunately Advantix II may not be right for your household — permethrin is toxic to cats (especially when wet). But if you don’t have cats, I highly recommend this product to all dog owners. Tick-borne diseases are no joke. Fleas are annoying — I’ve had to go through the nightmare of clearing an infestation — but at least they just suck blood without causing life-threatening illness. Ticks, on the other hand, can transmit Lyme, Ehrlichia, Rocky Mountain spotted fever, and more. So if you live somewhere warm, humid, grassy, or deer-heavy — do your dog a favor and get Advantix II. It’s been a lifesaver for us.
T**L
Works to Keep My Home Flea Free
This is My go to for flea protection. My vet recommended these drops and since we haven’t had dogs, we have always used them, and I have never found a flea. After we put these on, we always have to make sure that we do not put their backs until it is nice and soaked in. Once it has soaked into their skin and we are able to give them a bath to get rid of the oily spot where we applied the medication. I have found these straps to be safe to use, I have never noticed any scratching or skin irritation. This product has protected my dogs, my yard and my house for over 5 years.
R**S
flea treatment for my dogs
This product helped somewhat but not as well as I hoped. It may have been my dogs needed stronger flea treatment due to how bad the infestation had become. I have used this product before on other dogs and it worked better for them.
R**F
No es el producto que se anuncia!
No es el producto de la foto ni de la descripción. Es el Advantix normal, el de la caja azul, nada de k9 ni versión 2.. es contra 4 tipos de insectos y no contra 8 .. Lo compré por qué supuestamente era la versión ii Me siento engañado, no lo devolví por qué me iba de viaje y necesitaba echarle algo ya, si no lo habría devuelto.
S**N
No vino en su caja original
Vino tarde y y no en la caja original si que traía instrucciones, pero además tarde
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