









🐾 Protect your big buddy from pests before they even bite!
K9 Advantix II XL is a vet-recommended, topical flea, tick, mosquito, biting fly, and lice treatment designed for dogs over 55 lbs. It kills fleas within 12 hours and repels pests on contact, preventing bites and disease transmission. The fragrance-free formula is waterproof after 24 hours and available over the counter in a convenient 4-month supply, making it an essential, hassle-free defense for your large dog’s health and comfort.













| Active Ingredients | Imidacloprid, Permethrin, Pyriproxyfen |
| Brand | K9 Advantix |
| Customer Reviews | 4.4 out of 5 stars 48,025 Reviews |
| Item Form | Topical |
| Item Volume | 16 Milliliters |
| Item Weight | 1.6 ounces |
| Scent | Unscented |
A**E
Works great awesome I definitely suggested
UPDATE I don’t know what y’all all your people take your dogs to the vets instead of showing them online here that they can’t walk. The fur is falling out of the bleeding. That’s ridiculous. Take your dog to the friggin neck. Let the vet determine the cause exactly and then if it’s in clause because of this then Put a negative and state the fact that you took him to a vet and the vet did test and it was the closet because I’ve been using this product for 25 years on my dogs back then and my new dogs now my dogs I had 16 years ago dogs I had 10 years ago dogs I had 13 years ago my 16 1/2 year old cocker spaniel has had this from the day he could actually have this And I have never had a problem with that on any of my dogs especially him you know it got rid of the fleas and I noticed a few texts very easy to get off compared when I didn’t use it like if I skipped a couple of months and they had a dick and I was like oh my God and then I would try to get it off and it was a hassle. I mean, it did not pull up. Come out whatever And so I put them back on this every month originally and if they get a tick and I see it. I just need tweezers and it just pops right off no eggs inside nothing no problem with the weather did not cause any of my dogs ever itch or lose hair so I think you people have an undergoing problem with your dog that you did not address Prior to use this. Yes, I’m gonna blame you. Yes I’m blaming all you that people that has undermining problems with their dog and you don’t take them to the vet and you add this product on top of them. Yes, it probably will do something like that. SO I REPEAT, TAKE YOUR DOG TO THE GD VETERINARIAN PROFESSIONAL LET THE PROFESSIONAL DO THEIR WORK !!!! Oh, I also have one dog right now. I have three of them English mastiff and I have one of them that sits at my back gate in the dirt never has fleas never has sticks never has any. He lays in the dirt 185 pound and his head I can look it out right now his head is in it. His whole body lengthwise is in it and I swear he digs holes just you know it makes it cool.. and there’s a picture of him laying at the fence in the dirt. He loves it. I check them every day. Nobody has fleas. Nobody has anything so you people are doing something wrong. I’m gonna blame all of you. They have a problem and I’ll say it again again again they have underlining problem TAKE THEM TO THE VET VETERINARIAN HAVE THE VET, VETERINARIAN, TECHNICIAN, AND DOCTOR EXAMINE THE DOG TAKE SKIN GRAPHS WHATEVER THE BEST HAS TO DO. DON’T BLAME THE PRODUCT UNLESS YOU DID THAT AND IF YOU DID IT AND THEN DOCTOR RUNS TEXT AND SAID YES, IT WAS CAUSED BY THAT PRODUCT. WELL HENCE THERE YOU GO AND IT’S THE PRODUCT FAULT BUT A 99.999% IT’S NOT THE PRODUCT. Started having dogs when we first got married we have we had seven English mastiffs yeah it’s addicting and they had puppies and everything so anyways I’ve been using this on my dogs from year 2000 and I use them before that on my other dog so I’ve always used it really and I love it. I mean, I swear by it this stuff is great. My dogs do not get flea or I mean I have to put a spray on them to detail the mosquitoes, but don’t see my bugs biting them. It’s pricey, but it’s worth it. You don’t wanna have your dogs get Lyme disease or you know from ticks, I really suggest this. No bother my dog knock on wood you know in the other thing is I don’t use this year around. I only use it from spring until after fall. I don’t feel I really needed in the winter time. It’s too cold outside for anything to live so I’m up Northeast And I don’t seem to have any problem and they’re not using it as soon as spring hits that’s that boom they’re on it.
Y**N
The safest and most effective tick protection - ticks fall off just from touching the fur
I brought my dog to West Virginia, and thank God for Advantix II — because I’ve been finding half-dead ticks every single day (no joke) in places where she sleeps or rests. At first, I was confused. I thought "repels ticks" meant it would work like bug spray does for mosquitoes, keeping them away completely. But after looking into the active ingredient, permethrin, I realized that in this case, “repel” means: once a tick touches the treated fur, it becomes so irritated or neurologically impaired that it can’t bite, can’t hang on, and eventually just falls off and dies. That’s still so much better than PetArmor, Frontline, or any of the oral preventatives (like Simparica or NexGard), which require the tick to bite the dog before it dies. No thanks. Every tick I’ve found so far had already dropped off my dog before it had a chance to bite her and feed — exactly what you want in a tick-heavy area. I’ve also tried Wondercide (cedar oil). It works okay for fleas, but it’s just not effective for ticks, especially not in the long term. Its protection wears off after 2–4 hours. I learned the hard way — my dog caught Lyme disease, developed joint pain and a limp. Thankfully, doxycycline helped and she’s okay now, but it required a full 28-day antibiotic course. I would never use oral flea/tick medications. Just ask around — you’ll hear plenty of stories about dogs having seizures after taking them. For me, that risk isn’t worth it. If you have a cat at home, unfortunately Advantix II may not be right for your household — permethrin is toxic to cats (especially when wet). But if you don’t have cats, I highly recommend this product to all dog owners. Tick-borne diseases are no joke. Fleas are annoying — I’ve had to go through the nightmare of clearing an infestation — but at least they just suck blood without causing life-threatening illness. Ticks, on the other hand, can transmit Lyme, Ehrlichia, Rocky Mountain spotted fever, and more. So if you live somewhere warm, humid, grassy, or deer-heavy — do your dog a favor and get Advantix II. It’s been a lifesaver for us.
W**R
Topical Parasite protection K9 Advantage ll
Thank you for this really good product. K9 Advantage ll is vet recommended for topical use on large dog. I say yes.
R**A
Always Comes Through! (Except for 1 of our dogs that is allergic!)
We've tried soooo many flea products over the years and honestly...most of them barely do anything for our dogs. K9 Advantix II is the one we always end up coming back to because it actually works! It works pretty quickly and it keeps them flea free for the whole month! It's also super easy to apply! That said...one of our dogs just can't handle it. We've seen bald spots and even more itching after using it, so definitely keep an eye on your pup when trying it for the first time. But for our other two dogs? Perfect results every time! We'll absolutely keep using it for them!
I**P
Great product for small dogs
My mom lives out in the rural sticks. Her herd of small dogs has thrived out there for years, usually with no attention paid to fleas and whatnot until it becomes a problem. The solution was always a flea bath, maybe some Adams spray, and they are good to go until the next time. I'm not sure which is most to blame, but between the recent hot weather and the addition of ~20 chickens to her zoo (which in turn brings in unknown numbers of flea and tick covered rodents to get into the chicken feed and predators to try to get chickens), the fleas are thriving outdoors. ....and after many years of inconsistent flea protection they were thriving on her dogs, who primarily live indoors. Now, I am working to combat an active flea infestation in her house. The first application of this stuff has the dogs happier and not scratching as much. With the help of some 1ml oral syringes, I was able to turn one XL dog dose into 4 XS to Medium doses with just over a Medium dose to spare. That makes it pretty darn cheap for a product that works really well. It is an active infestation, so they are bound to get some fleas here and there and scratch a bit. It comes with the territory. Until the fleas are knocked down outdoors and until their life cycle is broken indoors, there will be fleas. Fighting an indoor flea infestation WILL take 6 weeks or a bit longer. I can't speak for how consistent this product is, as most products can have a dud here and there, but I have serious doubt with regard to all the people giving negative reviews because their dog got a few fleas after this product was applied. I don't know their back story, but fleas don't just sprout from the air and ticks are unlikely to fall off in a day. Odds are they have a yard and/or house full of fleas (just like I'm dealing with) and are expecting this to work miracles. It won't. Also, could be that they applied it to the dog's fur rather than on the dog's skin where it can be adsorbed. First off, CONTROL THE WILD FLEAS. Use an IGR in and around your house, and also get the proper microencapsulated pesticide for your usage case. If you have no cats around, permethrin based is great - like Onslaught Fastcap, Bifen I/T, or whatever indoor bug spray from the local hardware store. Wet down every bit of flooring, every baseboard, every access point. Let it dry before you let anyone/anything back in. Repeat every 2 weeks. If there are cats, use something cat safe like some hippie plant oil based garbage that needs to be applied every few days or do your own research and find an effective product. Get some insecticide granules and a spreader for your lawn. If cats, use Sevin or some hippie formulation (or whatever). If no cats, you have more options including Bifen L/P, Spectracide Triazicide, Talstar PL -- or even a cat-safe hippie formula if you just want use a less effective product and apply it way more often. Always wet the granules down after spreading. There is rarely a magic bullet when you're fighting nature.
C**T
Only thing that works
K9 Advantix 2 is the only thing that works for the itchy bugs here in Oklahoma. This is a 2 pack for XL dogs. I bought it for my corgis, splitting one tube between them (they're 30lbs each). I find it to be a much more cost effective way of treating them. Easy to use, simply run the open tube up their spine from tail to collar. Just avoid giving them a bath for a few days. Product doesn't work "instantly". It takes a day or two to kick in.
K**B
Fast shipping great product
Good product always works well with our dogs without any reactions easy ordering super fast shipping with Amazon. You can’t go wrong.
G**V
Not 100% Effective
It’s about 40% effective. Better off spending the extra $$ on the prescription grade stuff @ the vet but this works in a pinch if you can’t get to a vet quick enough.
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