---
product_id: 715574302
title: "Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats with 1% Hydrocortisone, 1.25oz"
brand: "zymox"
price: "$109.41"
currency: USD
in_stock: true
reviews_count: 5
category: "Zymox"
url: https://www.desertcart.us/products/715574302-zymox-advanced-formula-otic-plus-enzymatic-ear-solution-for-dogs
store_origin: US
region: United States of America
---

# 1% Hydrocortisone soothes itching & redness 1.25oz easy-drop applicator LP3 Enzyme System penetrates biofilms Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats with 1% Hydrocortisone, 1.25oz

**Brand:** zymox
**Price:** $109.41
**Availability:** ✅ In Stock

## Summary

> 🐾 Clear ears, happy pets — relief that’s a drop ahead!

## Quick Answers

- **What is this?** Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats with 1% Hydrocortisone, 1.25oz by zymox
- **How much does it cost?** $109.41 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/715574302-zymox-advanced-formula-otic-plus-enzymatic-ear-solution-for-dogs)

## Best For

- zymox enthusiasts

## Why This Product

- Trusted zymox brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Fast-Acting Relief:** 1% Hydrocortisone calms inflammation and itching within days
- • **No Pre-Cleaning Needed:** Gentle application without stressful ear pre-cleaning for your pet’s comfort
- • **Vet-Trusted Since 1998:** Clinically proven formula backed by decades of veterinary expertise
- • **Biofilm-Busting Enzymes:** Advanced LP3 Enzyme System targets stubborn microorganisms for deep cleaning
- • **Cruelty-Free & Made in USA:** Ethically produced with premium quality standards for conscious pet parents

## Overview

Zymox Advanced Formula Otic Plus is a veterinarian-recommended enzymatic ear solution for dogs and cats of all ages. Featuring the patented LP3 Enzyme System, it penetrates and breaks down biofilms caused by bacteria, fungi, and yeast, while 1% hydrocortisone provides fast relief from itching and redness. This gentle, no pre-cleaning formula is easy to apply and safe for regular use, making it an essential part of proactive pet ear care. Proudly made in the USA and cruelty-free, it’s a trusted choice for maintaining healthy, irritation-free ears.

## Description

Trusted by Veterinarians since 1998. ZYMOX Ear Solution with hydrocortisone aids in managing problematic ears on all animals including dogs and cats of any age. The patented LP3 Enzyme System delivers a potent formula to maximize the power of this product, without traumatic pre-cleaning and application. Otic Plus system works to penetrate deeper into the underlying bacteria's protective biofilm.1% Hydrocortisone is added for comfort. Use once daily for 7 to 14 days. For maintaining clean and healthy ears after the course of Ear Solution, use ZYMOX Ear Cleanser weekly. This product is proudly made in the USA. Animal Cruelty-Free and is never tested on animals. Item dimensions; 1.88"L x 1.13"W x 3.88"H, 1.25 Fluid Ounces (37ml).

Review: My dog occasionally gets ear irritation — shaking his head, scratching, and redness inside the ear. It’s stressful to watch, and I always want to address it quickly before it turns into something worse. This Zymox Otic Plus has been a lifesaver for us. What I like is that it contains 1% hydrocortisone, which helps calm inflammation and itching. Within a couple of days, I noticed he wasn’t shaking his head as much, and the redness started to look better. It seems to soothe pretty quickly. The dropper tip makes it easy to apply, and I gently massage the base of the ear as directed. It’s simple to use and doesn’t require pre-cleaning, which makes the process much less stressful for both of us. Of course, for severe or recurring infections I would still consult a vet, but for mild flare-ups and irritation, this has worked really well in our experience. If your dog or cat deals with occasional ear redness or itching, this is definitely worth having in your pet care kit. It’s effective, easy to apply, and brought noticeable relief within a few days.
Review: Wow! My dog had what I interpreted as excessive wax build up in his ear. He’s a feisty little guy and I could not get on top of it with mere cleaning and hair trimming. With a yeasty smell I turned to this product. The debris that came out of his ear was phenomenal, and now he is irritation free with a very clean ear canal. This product is highly recommended.

## Features

- Cat and dog ear cleaner, soothes recurrent ear issues, itching and redness, for pets of all ages
- Relief from stubborn ear problem-causing microorganisms that form complex, irritating biofilms
- Gentle formula helps relieve painful ear issues caused by resistant germs, fungi and yeast
- Pet ear solution, no pre-cleaning of painful ears needed; safe, natural alternative to medication
- LP3 Enzyme System to help clear ear exudate; 1% Hydrocortisone for itchy ears

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0066VLPGA |
| Allergen Information | Abalone Free |
| Batteries Included | No |
| Best Sellers Rank | #8,464 in Pet Supplies ( See Top 100 in Pet Supplies ) #34 in Dog Ear Care #202 in Cat Health Supplies |
| Color | Original Version |
| Customer Reviews | 4.7 4.7 out of 5 stars (12,640) |
| Date First Available | 16 October 2013 |
| Item Weight | 36.8 g |
| Item model number | 441125 |
| Number of Items | 1 |
| Pet Life Stage | All Life Stages |
| Pet Type | Cat, Dog, Kitten, Pet, Puppy |
| Product Dimensions | 19.69 x 10.8 x 9.53 cm; 36.85 g |
| Quantity | 1 |
| Size | 55 g |
| Specific Uses | EAR |
| batteries required | No |

## Images

![Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats with 1% Hydrocortisone, 1.25oz - Image 1](https://m.media-amazon.com/images/I/512WnsXPqIL.jpg)

## Questions & Answers

**Q: How is Zymox Plus different from Zymox (with the blue label)?  both say 1.0 hydrocortisone.**
A: My veterinarian said just to use the regular Zymox. It’s $10 cheaper and has the exact same ingredient. I looked it up myself. You can see the active ingredient in the inactive ingredient. Everything is the same.

It’s kind of like the namebrand Excedrin. They they packaged their product in different ways. They have Excedrin for headaches Excedrin for migraine. Exactly the same product. A lot of companies do that apparently.

Hope this helps

**Q: how do you get all the wax off the inside of the ears where it flushes out from the ear drops**
A: This is a bit thicker, kind of like the consistency of neosporin, so if your dogs ears are really wax-y right now, I would suggest doing a light cleaning before putting this in the ears. Once you put the zymox into the ear, rub your dogs ears kind of in a circular motion to help massage the solution down into the ear canal, and then just let it sit and do it's thing. Over time there will be less wax build up to clean out before applying the ointment. I now put it in my dogs ears about once every 10 to 15 days, just as maintenance and care, without needing any wax clean up before hand or afterwards.

**Q: Is this supposed to be liquidy/thin like water (not thick)? What I received is a different consistency than the thicker regular zymox I'm used to.**
A: I ordered and received a bottle this week and the solution is much thinner than the previous zymox plus otic-hc advanced formula bottles I've ordered. I haven't used it yet but just by shaking the bottle I can tell it is very liquidy compared to the bottle I have left over. I also compared the boxes and the box I received this week looks different as well. The font is different and the box has a different texture. I also read the paper inside and noticed a major typo on the one I just received. Instead of spelling "externa" they spelled "exernna" 🤦🏽‍♀️ The boxes have different lot numbers and the box that I have already opened has a later expiration date than the box I just received. I hope they didn't send me a knock off. This enzymatic solution usually works wonders on my Boxer and completely cures her ear infections when I use it as directed. I will update you on the effectiveness of the bottle I just received after I use it.

**Q: is this the same as Mometamax 15g**
A: No Different item Mometamax is stronger and is prescription medication.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by A***R on 24 February 2026*

My dog occasionally gets ear irritation — shaking his head, scratching, and redness inside the ear. It’s stressful to watch, and I always want to address it quickly before it turns into something worse. This Zymox Otic Plus has been a lifesaver for us. What I like is that it contains 1% hydrocortisone, which helps calm inflammation and itching. Within a couple of days, I noticed he wasn’t shaking his head as much, and the redness started to look better. It seems to soothe pretty quickly. The dropper tip makes it easy to apply, and I gently massage the base of the ear as directed. It’s simple to use and doesn’t require pre-cleaning, which makes the process much less stressful for both of us. Of course, for severe or recurring infections I would still consult a vet, but for mild flare-ups and irritation, this has worked really well in our experience. If your dog or cat deals with occasional ear redness or itching, this is definitely worth having in your pet care kit. It’s effective, easy to apply, and brought noticeable relief within a few days.

### ⭐⭐⭐⭐⭐ Review
*by J***S on 22 February 2026*

Wow! My dog had what I interpreted as excessive wax build up in his ear. He’s a feisty little guy and I could not get on top of it with mere cleaning and hair trimming. With a yeasty smell I turned to this product. The debris that came out of his ear was phenomenal, and now he is irritation free with a very clean ear canal. This product is highly recommended.

### ⭐⭐⭐⭐⭐ Review
*by J***I on 3 February 2026*

I use this for my pups whenever I notice scratching at their ears. It is a Godsend. Interestingly, while at the vet in the last exam, I noticed a large bottle of Zy on the countertop. The Vet said it was very effective, and what they use for treatment. Sometimes they only need it a few days to take the redness and itching away. I can see relief in Julia as soon as I treat her. This product comes always within two days of the order, never an issue, great product, my pups appreciate.

## Frequently Bought Together

- Zymox Advanced Formula Otic Plus Enzymatic Ear Solution for Dogs and Cats with 1% Hydrocortisone, 1.25oz
- Zymox Advanced Enzymatic Ear Wipes for Dogs and Cats - for Dirty, Waxy, Smelly Ears - Premium Strength Ear Cleaner Wipes - Non-Irritating - Hypoallergenic - 100 ct
- Zymox Ear Cleanser Solution for Dogs and Cats, 4oz

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-03-17*