---
product_id: 6543410
title: "12 Hour 600 mg Guaifenesin Extended-Release Tablets for Excess Mucus Relief, Expectorant Aids Excess Mucus Removal, Chest Congestion Relief, 20 Bi-Layer Tablets | Guaifenesin Expectorant, Extended-Release Formula, Bi-Layer Tablet, For Ages 12+"
brand: "mucinex"
price: "$30.80"
currency: USD
in_stock: true
reviews_count: 10
category: "Mucinex"
url: https://www.desertcart.us/products/6543410-12-hour-600-mg-guaifenesin-extended-release-tablets-for-excess
store_origin: US
region: United States of America
---

# 12-hour extended-release 600 mg guaifenesin per tablet thins & loosens mucus for chest relief 12 Hour 600 mg Guaifenesin Extended-Release Tablets for Excess Mucus Relief, Expectorant Aids Excess Mucus Removal, Chest Congestion Relief, 20 Bi-Layer Tablets | Guaifenesin Expectorant, Extended-Release Formula, Bi-Layer Tablet, For Ages 12+

**Brand:** mucinex
**Price:** $30.80
**Availability:** ✅ In Stock

## Summary

> 🫁 Clear lungs, clear mind — conquer your day with Mucinex!

## Quick Answers

- **What is this?** 12 Hour 600 mg Guaifenesin Extended-Release Tablets for Excess Mucus Relief, Expectorant Aids Excess Mucus Removal, Chest Congestion Relief, 20 Bi-Layer Tablets | Guaifenesin Expectorant, Extended-Release Formula, Bi-Layer Tablet, For Ages 12+ by mucinex
- **How much does it cost?** $30.80 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/6543410-12-hour-600-mg-guaifenesin-extended-release-tablets-for-excess)

## Best For

- mucinex enthusiasts

## Why This Product

- Trusted mucinex brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Powerful 600mg Dose:** Clinically proven guaifenesin strength to break up mucus and clear your lungs efficiently.
- • **Convenient & Reliable:** 20 easy-to-swallow tablets in a blister pack, perfect for your busy lifestyle and on-the-go relief.
- • **All-Day Congestion Control:** Bi-layer tablet delivers immediate + extended relief for up to 12 hours, so you stay unstoppable.
- • **Trusted by Experts & Peers:** #1 doctor & pharmacist recommended expectorant—join millions who rely on Mucinex.
- • **Breathe Freely, Work Confidently:** Non-drowsy formula keeps you sharp and productive while beating chest congestion.

## Overview

Mucinex 12 Hour Extended-Release Tablets feature a patented bi-layer design delivering 600 mg of guaifenesin for fast-acting and long-lasting chest congestion relief. Clinically proven to thin and loosen mucus, these non-drowsy tablets provide up to 12 hours of effective expectorant action, trusted by healthcare professionals and millions of users. Ideal for adults 12+, this blister-packaged product supports productive coughs and helps you breathe easier through cold and flu season.

## Description

From the Manufacturer When mucus builds up in your chest, congestion can get in the way of your day. Mucinex extended-release bi-layer tablets fight bothersome chest congestion for 12 hours so you can focus on your life and forget about congestion.Fast-Acting, Long-Lasting ReliefMucinex extended-release tablets break up the mucus that causes chest congestion, providing you with fast-acting and long-lasting relief. With 12 hours of relief from chest congestion, you can make it through a workday without congestion getting in your way.Get 12 Hours of ReliefOnly Mucinex has an extended release bi-layer tablet to deliver congestion relief. The first layer is absorbed quickly by your body for fast-acting relief. The other layer dissolves slowly to continue relieving your chest congestion for 12 hours.Mucinex: #1 with Doctors, Pharmacists, and ConsumersYou're too busy with family, home, and work to let sickness slow you down. You need a brand you can trust to get the job done. That's why there's Mucinex. Mucinex is the #1 doctor recommended1, #1 pharmacist recommended2 3 and #1 most popular4 OTC expectorant brand. Mucinex products all have the dependable, mucus-busting power to show Mr. Mucus the way out of your system so you can keep up with life.What's in the BoxOne box of Mucinex extended-release bi-layer tablets (20 tablets per box).MucinexRelieves these Symptoms:Relieves chest congestionThins and breaks up mucus to make coughs more productiveUse as directed.Mucinex Has Products for All of Your Worst Symptoms 12 Hour Relief (Tablets)Chest CongestionDry CoughNasal Congestion Maximum Strength Mucinexx Mucinexx Maximum Strength Mucinex DMxx Mucinex DMxx Maximum Strength Mucinex Dxx Mucinex Dxx1 Mucinex is the #1 doctor-recommended OTC expectorant among internists, general practitioners, and family practitioners. IMS Health, NDTI (National Disease Therapeutic Index), MAT 52 Weeks Ending March 2012.2 OTC Expectorants: 2012 Survey of Pharmacist Recommendations: Pharmacy Times, June 2012.3 Among Adult Expectorants and Adult Multisymptom Cold or Flu products. Pharmacy Today Annual Over-the-Counter Survey, February 2012.4 Based on Symphony IRI unit sales data for the 52-week period ending November 25, 2012. Product Description Are you searching for reliable chest congestion relief for adults? Look no further than Mucinex 12 Hour Expectorant for excess mucus relief. Featuring a robust 600mg of guaifenesin, this top-notch expectorant thins and loosens mucus thereby making coughs more productive. When the cold and flu season hits, trust Mucinex for powerful chest congestion relief. Our original bi-layer tablet provides immediate and extended-release and lasts up to 12 hours. Use as directed, for Adults and Children 12 years of age and over.

Review: One Tablet Lasted 24 Hours! - Years ago I seem to remember a kind pharmacist telling me that I should get a cough syrup with Guaifenesin in it because that would help clear my ears when they got blocked up. I tried it, it worked, I was a believer. Now I have seen the benefits of Guaifenesin when dealing with thick green mucous that was blocking up my nasal passages and lungs. I really got hit hard this year after not being sick since 2020! Whatever is out there now if way more virulent and I was at the point where I was choking every time I was drinking water and this was making me throw up. So I could not drink water easily, I did not feel like eating and basically I was quite sick. Then yesterday I took ONE tablet of Mucinex 12 hour extended release tablets and the results were amazing. Today I do not have the green mucus and my lungs are nearly all clear and I have no more sinus blockage. Basically I can breathe again without feeling like I'm going to cough too much. I am still coughing a little and that is subsiding. I am just interested to know that a 12 hour tablet could have effects for a good 24 hours. I did feel really sleepy last night when I would wake up so it may cause some drowsiness. Usually I can wake up, do things and then go back to bed. So the duration for my body chemistry was 24 hours. I think this is a great value since a few tablets are probably going to solve your issues. Please consult with a doctor if you have any concerns. I am not a doctor so this review is not medical advice. I'm just glad to be alive and happier than yesterday! I can breathe through my nose again fine without using a serious decongestant besides a nasal spray. I knew Guaifenesin was good for draining ears but I had no idea it was good for getting mucus out of lungs and nasal passages. Happy to have this new information! ~The Rebecca Review
Review: Really works - Mucinex 12 Hour 600 mg Guaifenesin has been a reliable product to keep on hand whenever congestion strikes. I purchased it to help with chest congestion and mucus buildup, and it worked exactly as intended. The extended release formula provides long lasting relief, so I didn’t have to take it constantly throughout the day. The tablets were easy to swallow, and I noticed that it helped loosen mucus, making it much easier to clear my chest and breathe comfortably. I also appreciated that it didn’t make me feel drowsy, which allowed me to go about my normal daily activities without feeling sluggish. The packaging was secure, and the expiration date was well into the future. As always, it’s important to stay hydrated while taking guaifenesin for the best results. Overall, this is an effective and dependable expectorant that has earned a permanent spot in my medicine cabinet. I would definitely purchase it again and recommend it to anyone looking for relief from chest congestion.

## Features

- EXCESS MUCUS RELIEF: Mucinex 12hr extended-release tablets pack a powerful punch with 600 mg guaifenesin expectorant, providing you with long-lasting chest congestion relief
- AIDS EXCESS MUCUS REMOVAL: Mucinex SE lasts up to 12 hours, provides chest congestion relief and makes coughs more productive
- EXPECTORANTS FOR ADULTS: Mucinex helps clear lungs by thinning & loosening mucus; Say goodbye to excess mucus, say hello to chest congestion relief
- EXTENDED RELEASE GUAIFENESIN: Experience long-lasting excess mucus relief with Mucinex's 12hr extended-release 600mg guaifenesin tablets; our original bi-layer tablets have both immediate & extended release
- COLD AND FLU MEDICINE FOR ADULTS: For powerful cough, cold, and flu multi-symptom relief, check out our range of Mucinex Fast-Max cold and flu medicines; Beat cold and flu symptoms with confidence
- USAGE: Use as directed; For ages 12+ years
- QUALITY YOU CAN TRUST: Mucinex uses carbomer that is manufactured without the use of benzene

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B000Z09S6W |
| Active Ingredients | Guaifenesin |
| Additional Features | Clinically Proven, Fast-Acting, Long-Lasting, Non-Drowsy |
| Age Range Description | Adult |
| Best Sellers Rank | #6,498 in Health & Household ( See Top 100 in Health & Household ) #34 in Cold & Flu Medicine #741 in Sales & Deals |
| Brand | Mucinex |
| Brand Name | Mucinex |
| Container Type | Blister Pack |
| Customer Reviews | 4.8 out of 5 stars 3,791 Reviews |
| Diet Type | Gluten Free |
| Dosage Form | Tablets |
| Flavor | Unflavored |
| Item Dimensions | 0.88 x 3.5 x 3.78 inches |
| Item Form | Tablet |
| Item Weight | 2 g |
| Item dimensions L x W x H | 0.88 x 3.5 x 3.78 inches |
| Manufacturer | Reckitt Benckiser Healthcare |
| Manufacturer Part Number | RAC00820 00820 |
| Model Name | Chest Congestion, Mucinex |
| Model Number | RAC00820 00820 |
| Net Content Count | 20 count |
| Net Content Weight | 16 ounces |
| Number of Items | 1 |
| Package Type Name | Blister |
| Product Benefits | Immediate and Extended Relief that lasts up to 12 hours. Mucinex pantented bi-layer tablet contains an immediate-release layer on one side and extended-release layer on the other side which allows extended relief for up to 12 hours Product Benefits Immediate and Extended Relief that lasts up to 12 hours. Mucinex pantented bi-layer tablet contains an immediate-release layer on one side and extended-release layer on the other side which allows extended relief for up to 12 hours See more |
| Specific Uses For Product | Cough |
| Target Audience | Unisex-Adults |
| Target Use Body Part | Whole Body |
| UPC | 363824008202 |
| Unit Count | 20 Count |

## Product Details

- **Brand:** Mucinex
- **Item Weight:** 2 g
- **Item dimensions L x W x H:** 0.88 x 3.5 x 3.78 inches
- **Specific Uses For Product:** Cough

## Images

![12 Hour 600 mg Guaifenesin Extended-Release Tablets for Excess Mucus Relief, Expectorant Aids Excess Mucus Removal, Chest Congestion Relief, 20 Bi-Layer Tablets | Guaifenesin Expectorant, Extended-Release Formula, Bi-Layer Tablet, For Ages 12+ - Image 1](https://m.media-amazon.com/images/I/71-9OY0oxHL.jpg)

## Available Options

This product comes in different **Size, Flavor** options.

## Questions & Answers

**Q: What is the size of these pills?**
A: they looked large to me I have trouble swallowing pills, but took a try and it went right down.They are tapered at the ends and smooth,you can taste them if you hold it too long like I did.but I paid $17 @ the local drug store for 20 pills.

**Q: My phlegm are generally throat which is the best one**
A: Expectorant is good to dissolve phlegm, help you to cough out the phlegm and ease cough and throat irritation.  cause little drowsiness

**Q: what is the expiration date?**
A: 06/2021

**Q: made in usa?**
A: Made in England!

## Customer Reviews

### ⭐⭐⭐⭐⭐ One Tablet Lasted 24 Hours!
*by T***W on May 17, 2026*

Years ago I seem to remember a kind pharmacist telling me that I should get a cough syrup with Guaifenesin in it because that would help clear my ears when they got blocked up. I tried it, it worked, I was a believer. Now I have seen the benefits of Guaifenesin when dealing with thick green mucous that was blocking up my nasal passages and lungs. I really got hit hard this year after not being sick since 2020! Whatever is out there now if way more virulent and I was at the point where I was choking every time I was drinking water and this was making me throw up. So I could not drink water easily, I did not feel like eating and basically I was quite sick. Then yesterday I took ONE tablet of Mucinex 12 hour extended release tablets and the results were amazing. Today I do not have the green mucus and my lungs are nearly all clear and I have no more sinus blockage. Basically I can breathe again without feeling like I'm going to cough too much. I am still coughing a little and that is subsiding. I am just interested to know that a 12 hour tablet could have effects for a good 24 hours. I did feel really sleepy last night when I would wake up so it may cause some drowsiness. Usually I can wake up, do things and then go back to bed. So the duration for my body chemistry was 24 hours. I think this is a great value since a few tablets are probably going to solve your issues. Please consult with a doctor if you have any concerns. I am not a doctor so this review is not medical advice. I'm just glad to be alive and happier than yesterday! I can breathe through my nose again fine without using a serious decongestant besides a nasal spray. I knew Guaifenesin was good for draining ears but I had no idea it was good for getting mucus out of lungs and nasal passages. Happy to have this new information! ~The Rebecca Review

### ⭐⭐⭐⭐⭐ Really works
*by S***A on June 20, 2026*

Mucinex 12 Hour 600 mg Guaifenesin has been a reliable product to keep on hand whenever congestion strikes. I purchased it to help with chest congestion and mucus buildup, and it worked exactly as intended. The extended release formula provides long lasting relief, so I didn’t have to take it constantly throughout the day. The tablets were easy to swallow, and I noticed that it helped loosen mucus, making it much easier to clear my chest and breathe comfortably. I also appreciated that it didn’t make me feel drowsy, which allowed me to go about my normal daily activities without feeling sluggish. The packaging was secure, and the expiration date was well into the future. As always, it’s important to stay hydrated while taking guaifenesin for the best results. Overall, this is an effective and dependable expectorant that has earned a permanent spot in my medicine cabinet. I would definitely purchase it again and recommend it to anyone looking for relief from chest congestion.

### ⭐⭐⭐⭐⭐ Mucinex works!
*by S***Y on July 25, 2026*

While I prefer the pills to the taste of the liquid, I have to note the pills are quite large. Bear that in mind when choosing. Fairly expensive for guafenesen which you can buy in any brand or cheaper with store brand or generic. Somehow I feel I had better success with the Mucinex brand so I'm paying the difference.

## Frequently Bought Together

- Mucinex Chest Congestion, Expectorant 12 Hour Extended Release Tablets, 20ct, 600mg Guaifenesin with Extended Relief of Chest Congestion Caused by Excess Mucus. Thins and Loosens Mucus
- Pre-Seed Fertility Lubricant, For Use by Couples Trying to Conceive
- Geritol Liquid Vitamin and Iron Supplement, Energy Support, Contains High Potency B-Vitamins and Iron, Pleasant Tasting, Easy to Swallow, No Artificial Sweeteners, Non-GMO, 12 Oz

---

## Why Shop on Desertcart?

- 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016
- 🌍 **Shop Globally** — Access 737+ million products across 21 categories
- 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price
- 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members)
- 🔒 **Secure Payments** — Trusted payment options with buyer protection
- ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews

**Shop now:** [https://www.desertcart.us/products/6543410-12-hour-600-mg-guaifenesin-extended-release-tablets-for-excess](https://www.desertcart.us/products/6543410-12-hour-600-mg-guaifenesin-extended-release-tablets-for-excess)

---

*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-08-22*