---
product_id: 6465317
title: "Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules"
brand: "life extension"
price: "$23.19"
currency: USD
in_stock: true
reviews_count: 13
category: "Life Extension"
url: https://www.desertcart.us/products/6465317-life-extension-tmg-trimethylglycine-encourages-healthy-homocysteine-levels-non-gmo
store_origin: US
region: United States of America
---

# Non-GMO, gluten-free & vegetarian Supports healthy homocysteine levels Made in USA with premium purity Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules

**Brand:** life extension
**Price:** $23.19
**Availability:** ✅ In Stock

## Summary

> ❤️ Elevate your heart game with science-backed TMG power!

## Quick Answers

- **What is this?** Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules by life extension
- **How much does it cost?** $23.19 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/6465317-life-extension-tmg-trimethylglycine-encourages-healthy-homocysteine-levels-non-gmo)

## Best For

- life extension enthusiasts

## Why This Product

- Trusted life extension brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Trusted Quality:** Manufactured in the USA with transparent Certificates of Analysis for every batch.
- • **Clean & Conscious:** Non-GMO, gluten-free, vegetarian formula crafted with the purest ingredients.
- • **Heart Health Hero:** Clinically backed TMG to maintain optimal homocysteine, a key cardiovascular biomarker.
- • **Longevity Essential:** Perfect companion for NMN/NR stacks to balance methylation and support cellular health.
- • **Flexible Supplementing:** Choose your style—easy-to-swallow capsules or versatile powder form.

## Overview

Life Extension TMG delivers a pure, scientifically supported trimethylglycine supplement designed to maintain healthy homocysteine levels, a critical marker for cardiovascular wellness. Available in vegetarian capsules or powder, this non-GMO, gluten-free formula is crafted in the USA to support heart health, methylation balance, and overall longevity.

## Description

Keep the beat on a healthy heart with TMG! TMG, aka trimethylglycine, is a well-researched amino acid that’s been linked to its cardiovascular health benefits since the 1950s. TMG benefits the heart primarily by helping to maintain already-normal homocysteine levels, which are an important biomarker of cardiovascular health. This TMG supplement is available both as liquid vegetarian capsules or in a convenient powder form. This formula is also non-GMO, gluten-free, vegetarian and manufactured in the USA.

Review: Clean, Simple, and Effective - This Life Extension TMG is a solid, no‑nonsense supplement. The capsules are easy to take, the formula is clean, and it fits well into a daily routine. A reliable option if you want straightforward support without any unnecessary additives.
Review: Essential Companion to NMN in My Longevity Stack - The primary reason for adding TMG when using NMN or NR is because they increase intracellular NAD⁺ levels which accelerates the activity of methyltransferase enzymes. This can create a significant demand for methyl groups and temporarily elevate homocysteine if methyl donors are insufficient. TMG serves as a methyl donor directly converting homocysteine back to methionine via the betaine-homocysteine methyltransferase pathway. Two capsules with breakfast provide exactly the 1–1.5 g range frequently cited in longevity-focused protocols. For anyone incorporating NMN, NR, or high-dose niacin into a longevity regimen, I consider TMG essential for maintaining methylation balance and minimizing potential homocysteine elevation. This particular TMG offering from Life Extension delivers reliable purity, potency, and value.

## Features

- TMG for heart health – TMG supplements help maintain normal homocysteine levels—a key biomarker of cardiovascular health.
- Well-researched amino acid – TMG’s heart health benefits have been documented since the 1950s.
- Take as capsules or powder – To make supplementing more convenient, TMG is available to take two different ways: as a capsule or in powder form, so you can choose what is best for you.
- Ingredients matter – We use only the finest raw ingredients with the quality and purity you deserve. The majority of our products are non-GMO, gluten-free and manufactured in the USA—and a Certificate of Analysis is available for every one.
- Live your healthiest life – We believe the answers to a healthier life are within reach, and that scientific research is the key to getting us there. That’s why so many of our formulas feature specific ingredients and amounts based on scientific studies.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00I509FZI |
| ASIN  | B00I509FZI |
| Age Range Description | Adult |
| Allergen Information | Gluten Free, Non-GMO |
| Best Sellers Rank | #6,509 in Health & Household ( See Top 100 in Health & Household ) #124 in Blended Vitamin & Mineral Supplements #781 in Sales & Deals |
| Brand Name | Life Extension |
| Color | Clear |
| Container Type | Bottle |
| Customer Reviews | 4.4 4.4 out of 5 stars (2,121) |
| Date First Available  | January 30, 2014 |
| Department  | Adults |
| Diet Type | Vegetarian |
| Dosage Form | Capsule |
| Flavor | Unflavored |
| Global Trade Identification Number | 00737870185963 |
| Is Discontinued By Manufacturer  | No |
| Item Dimensions | 2 x 2 x 3.75 inches |
| Item Form | Capsule |
| Item Nype Name | Trimethylglycine Supplement |
| Item Weight | 3.2 ounces |
| Item model number  | 01859 |
| Manufacturer | Life Extension |
| Manufacturer  | Life Extension |
| Manufacturer Part Number | 01859 |
| Material Features | Vegetarian |
| Material Type Free | Gluten Free, Non-GMO |
| Model Name | TMG |
| Model Number | 01859 |
| Number of Items | 1 |
| Primary Supplement Type | Trimethylglycine (TMG) |
| Product Benefits | Encourages whole-body health, Helps inhibit inflammatory factors to encourage cardiovascular health, Helps maintain healthy mitochondrial function, Promotes healthy homocysteine levels already within normal range, Supports already-healthy blood pressure levels |
| Product Dimensions  | 2 x 2 x 3.75 inches; 3.2 ounces |
| Special Ingredients | Trimethylglycine (TMG) |
| Specific Uses For Product | Heart Health |
| Total Servings Per Container | 30.0 |
| UPC | 737870185963 |
| Unit Count | 60 Count |

## Product Details

- **Brand:** Life Extension
- **Diet Type:** Vegetarian
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Item Weight:** 3.2 ounces
- **Item dimensions L x W x H:** 2 x 2 x 3.75 inches
- **Primary Supplement Type:** Trimethylglycine (TMG)
- **Special Ingredients:** Trimethylglycine (TMG)
- **Unit Count:** 60 Count

## Images

![Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules - Image 1](https://m.media-amazon.com/images/I/61R4JGBT8UL.jpg)
![Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules - Image 2](https://m.media-amazon.com/images/I/71TeI78hX7L.jpg)
![Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules - Image 3](https://m.media-amazon.com/images/I/61pdAQ-z-IL.jpg)
![Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules - Image 4](https://m.media-amazon.com/images/I/71BuigiehyL.jpg)
![Life Extension TMG, trimethylglycine, Encourages Healthy homocysteine Levels, Non-GMO, Gluten-Free, Vegetarian, 60 Capsules - Image 5](https://m.media-amazon.com/images/I/81Dq7H6r2iL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: What is the supplement TMG used for?**
A: There are several benefits to taking TMG. This compound supports healthy homocysteine levels, supports heart and liver health, maintains healthy mitochondrial function and promotes a healthy inflammatory response.

**Q: What foods are high in TMG?**
A: The primary dietary source of TMG is wheat bran, although this compound can be found in other cereal grains. TMG can also be made in the body via the essential nutrient choline. Other foods high in TMG include beets, broccoli, spinach and shellfish.

**Q: When should I take TMG?**
A: You should always follow the instructions on any supplement’s label. TMG capsules are generally intended to be taken 1000 mg at a time in the morning, but you should consult with your healthcare provider if you are unsure of the dosage.

**Q: Does TMG support a healthy inflammatory response?**
A: TMG is known to support many different systems throughout your body. One of its many benefits is supporting a healthy inflammatory response. In particular, TMG can help inhibit inflammatory factors to support heart health.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Clean, Simple, and Effective
*by O***A on January 31, 2026*

This Life Extension TMG is a solid, no‑nonsense supplement. The capsules are easy to take, the formula is clean, and it fits well into a daily routine. A reliable option if you want straightforward support without any unnecessary additives.

### ⭐⭐⭐⭐⭐ Essential Companion to NMN in My Longevity Stack
*by P***O on December 7, 2025*

The primary reason for adding TMG when using NMN or NR is because they increase intracellular NAD⁺ levels which accelerates the activity of methyltransferase enzymes. This can create a significant demand for methyl groups and temporarily elevate homocysteine if methyl donors are insufficient. TMG serves as a methyl donor directly converting homocysteine back to methionine via the betaine-homocysteine methyltransferase pathway. Two capsules with breakfast provide exactly the 1–1.5 g range frequently cited in longevity-focused protocols. For anyone incorporating NMN, NR, or high-dose niacin into a longevity regimen, I consider TMG essential for maintaining methylation balance and minimizing potential homocysteine elevation. This particular TMG offering from Life Extension delivers reliable purity, potency, and value.

### ⭐⭐⭐⭐⭐ Great support alongside methylated B vitamins
*by J***R on February 11, 2026*

This has been a great addition alongside my methylated B vitamins. I take the TMG at night since it makes me a bit sleepy, and it feels like a supportive combo for overall restoration and balance. Clean formula and easy to incorporate into my routine.

## Frequently Bought Together

- Life Extension TMG 500 mg – Trimethylglycine Supplement – Encourages Healthy Homocysteine Levels – Gluten-free – Non-gmo – Vegetarian – 60 Liquid Vegetarian Capsules
- Life Extension BioActive Complete B-Complex, Heart, Brain and Nerve Support, Healthy Energy, Metabolism, Complete B Complex, 60 Vegetarian Capsules
- Life Extension Neuro-Mag Magnesium L-Threonate, Magnesium L-threonate, Memory Health, Quick Thinking, Cognitive Health Support, Vegetarian, Non-GMO, 90 Vegetarian Capsules

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-03-17*