---
product_id: 619971874
title: "Depend Night Defense Adult Diapers for Men, Large, 22 Count"
brand: "depend"
price: "$127.61"
currency: USD
in_stock: true
reviews_count: 13
category: "Depend"
url: https://www.desertcart.us/products/619971874-depend-night-defense-adult-diapers-for-men-large-22-count
store_origin: US
region: United States of America
---

# 30x weight absorbency 12-hour overnight protection underwear-like comfort Depend Night Defense Adult Diapers for Men, Large, 22 Count

**Brand:** depend
**Price:** $127.61
**Availability:** ✅ In Stock

## Summary

> 💼 Stay dry, stay sharp — overnight protection that works as hard as you do.

## Quick Answers

- **What is this?** Depend Night Defense Adult Diapers for Men, Large, 22 Count by depend
- **How much does it cost?** $127.61 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/619971874-depend-night-defense-adult-diapers-for-men-large-22-count)

## Best For

- depend enthusiasts

## Why This Product

- Trusted depend brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Tailored for Men:** Large size fits 35–43" waist perfectly, combining secure fit with breathable, latex-free materials.
- • **All-Night Confidence:** Up to 12 hours of reliable overnight protection so you wake up worry-free and refreshed.
- • **Discreet Comfort Fit:** Designed like real underwear with soft, cotton-like fabric that moves with you silently.
- • **Odor Neutralizing Tech:** ODORBLOCK technology ensures up to zero odors, keeping you fresh and confident all night long.
- • **Maximum Absorbency Power:** Depend’s DryShield core locks in 30x its weight, turning liquid into gel for unbeatable dryness.

## Overview

Depend Night Defense Adult Diapers for Men (Large, 22 Count) deliver up to 12 hours of maximum absorbency with a DryShield core that absorbs 30x its weight and locks in odors using ODORBLOCK technology. Designed for discreet, underwear-like comfort with soft, cotton-like fabric, these disposable incontinence underwear provide reliable overnight protection for men with a 35–43" waist, ensuring dryness, confidence, and freshness through the night.

## Description

Depend Night Defense Underwear for Men delivers up to 12 hours of protection and underwear-like comfort. Offering up to zero odor, our adult diapers for men are made with ODORBLOCK technology that helps neutralize and lock in odors. Depend Night Defense helps protect you from overnight bladder leaks thanks to our Dryshield core that absorbs 30x its weight* and turns liquid into gel. More comfortable than ever, our incontinence underwear for men is made with cotton-like fabric and materials that are softer and quieter than before. A moisture-wicking layer for dryness provides gentle protection you can trust through the night. Depend Night Defense incontinence underwear for men is available in three sizes: size small/medium (26–34" waist), size large (35–43" waist) and size extra-large (44–54" waist). For daytime protection, try Depend Fresh Protection Underwear. Packaging may vary. (*super absorbent material absorbs 30x its weight)

Review: Amazing for the price! - These diapers were perfect, they handle large quantities of liquid and fit generally quite snug on the body. The only problem is if you wet it enough the bottom lining around the lower crotch can start to lift off from your skin, but so far no leaks :)
Review: BHOW TO MAKE DEPENDS WORK BETTER FOR YOU - My husband always wore brand but in a large size. He has lost a lot of wait and decided to switch to the small/medium size. He likes them much better because they fit him better. He no longer has to add padding to stay completely dry.

## Features

- WHAT'S INCLUDED — 22 count of Depend Night Defense Adult Incontinence Underwear for Men, maximum absorbency, size large (35–43" waist)
- OUTSTANDING ABSORBENCY — Depend DryShield core absorbs 30x its weight* to help keep you dry and turns liquid into gel (*super absorbent material absorbs 30x its weight)
- UP TO 12 HOURS OF PROTECTION — Designed for up to 12 hours of overnight protection and worry-free sleep
- UNDERWEAR-LIKE COMFORT — Our disposable incontinence underwear designed for men feels like real underwear for superior comfort** and confidence, even overnight (**vs. previous Depend Night Defense)
- UP TO ZERO ODOR — Depend underwear has up to zero odors thanks to ODORBLOCK technology that helps neutralize and lock in odors

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0CM4RH6XP |
| Age Range (Description) | Adult |
| Age Range Description | Adult |
| Best Sellers Rank | #563 in Health & Household ( See Top 100 in Health & Household ) #8 in Incontinence Protective Briefs & Underwear |
| Brand | Depend |
| Brand Name | Depend |
| Color | Grey |
| Customer Reviews | 4.4 out of 5 stars 10,061 Reviews |
| Effective Absorbency Hours | 12 |
| Global Trade Identification Number | 00036000551372, 10036000551379 |
| Incontinence Protector Size | Large |
| Incontinence Protector Type | Adult Incontinence Underwear |
| Item Dimensions | 5.7 x 8.34 x 17 inches |
| Item Length | 5.7 inches |
| Item Weight | 3.1 pounds |
| Lining Description | Cotton |
| Manufacturer | Kimberly-Clark Corp. |
| Manufacturer Part Number | 10036000551379 |
| Material | Polypropylene |
| Material Type | Polypropylene |
| Material Type Free | Latex Free |
| Model Number | 10036000551379 |
| Number of Items | 1 |
| Pattern | Solid |
| Recommended Uses For Product | Urine Protection |
| Reusability | Disposable |
| Size | Large |
| Target Audience | Men, Unisex-Adults |
| UPC | 036000551372 |
| Unit Count | 22 Count |
| Weight Range | 68-100 kg |

## Product Details

- **Age Range (Description):** Adult
- **Brand:** Depend
- **Color:** Grey
- **Incontinence Protector Type:** Adult Incontinence Underwear
- **Number of Items:** 1

## Images

![Depend Night Defense Adult Diapers for Men, Large, 22 Count - Image 1](https://m.media-amazon.com/images/I/81PBxRPkw3L.jpg)
![Depend Night Defense Adult Diapers for Men, Large, 22 Count - Image 2](https://m.media-amazon.com/images/I/81ij8ulpA5L.jpg)
![Depend Night Defense Adult Diapers for Men, Large, 22 Count - Image 3](https://m.media-amazon.com/images/I/61QwxaP6BlL.jpg)
![Depend Night Defense Adult Diapers for Men, Large, 22 Count - Image 4](https://m.media-amazon.com/images/I/71I6UNufluL.jpg)
![Depend Night Defense Adult Diapers for Men, Large, 22 Count - Image 5](https://m.media-amazon.com/images/I/81nOdqm9AaL.jpg)

## Available Options

This product comes in different **Size, Unit Count** options.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Amazing for the price!
*by J***X on August 6, 2026*

These diapers were perfect, they handle large quantities of liquid and fit generally quite snug on the body. The only problem is if you wet it enough the bottom lining around the lower crotch can start to lift off from your skin, but so far no leaks :)

### ⭐⭐⭐⭐⭐ BHOW TO MAKE DEPENDS WORK BETTER FOR YOU
*by T***A on August 24, 2026*

My husband always wore brand but in a large size. He has lost a lot of wait and decided to switch to the small/medium size. He likes them much better because they fit him better. He no longer has to add padding to stay completely dry.

### ⭐⭐⭐⭐⭐ Very effective
*by N***E on August 27, 2026*

Very effective My only problem is amazon delivered these just in the original packaging It's humiliating enough that I have to use these . I don't want all my neighbors knowing.

## Frequently Bought Together

- Depend Night Defense Adult Incontinence Underwear for Men, Disposable, Overnight, Large, Grey, 22 Count, Packaging May Vary
- Depend Fresh Protection Adult Incontinence Underwear for Men, Disposable, Maximum, Large, Grey, 28 Count, Packaging May Vary
- Depend Incontinence Guards/Incontinence Pads for Men/Bladder Control Pads, Maximum Absorbency, 104 Count (2 Packs of 52), Packaging May Vary

---

## Why Shop on Desertcart?

- 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016
- 🌍 **Shop Globally** — Access 737+ million products across 21 categories
- 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price
- 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members)
- 🔒 **Secure Payments** — Trusted payment options with buyer protection
- ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews

**Shop now:** [https://www.desertcart.us/products/619971874-depend-night-defense-adult-diapers-for-men-large-22-count](https://www.desertcart.us/products/619971874-depend-night-defense-adult-diapers-for-men-large-22-count)

---

*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-09-24*