--- product_id: 51457228 title: "Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules" brand: "zylkene" price: "$104.92" currency: USD in_stock: true reviews_count: 13 category: "Zylkene" url: https://www.desertcart.us/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg store_origin: US region: United States of America --- # natural alpha casozepine for large dogs 30-60kg 450mg calming dose Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules **Brand:** zylkene **Price:** $104.92 **Availability:** ✅ In Stock ## Summary > 🐾 Calm, collected, and confidently social – because your big dog deserves peace of mind. ## Quick Answers - **What is this?** Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules by zylkene - **How much does it cost?** $104.92 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg) ## Best For - zylkene enthusiasts ## Why This Product - Trusted zylkene brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Tailored for Large Dogs:** Precisely dosed 450mg capsules designed for dogs weighing 30-60kg to ensure effective relief - • **Versatile Stress Support:** Ideal for fireworks, social events, travel, and any short-term stressful situation your dog faces - • **Effortless Administration:** Unflavored capsules easily sprinkled on food for stress relief without the hassle - • **Vet-Trusted Calming Power:** UK’s No.1 veterinary calming supplement trusted by professionals and pet parents alike - • **Natural & Clinically Proven:** Harnesses alpha casozepine, a natural milk protein clinically shown to reduce stress and anxiety ## Overview Zylkene Calming Supplements deliver a clinically proven 450mg dose of natural alpha casozepine per capsule, specifically formulated for large dogs (30-60kg). Trusted as the UK’s top veterinary calming aid, it supports pets through short-term stressors like loud noises and social gatherings. Easy to administer and allergen-free, this supplement helps your dog stay relaxed and focused, enhancing their wellbeing during challenging moments. ## Description From the manufacturer UK's No.1 veterinary* calming supplement Contains casein, a natural milk protein with clinically proven calming effects Helps pets cope with challenging situations inside or outside the home Review: OMG I cant praise this enough - If I could give this ten stars I would ! We have an old dog suffering from dementia. He is physically in excellent health but was suffering from severe stress and a condition named Sundown which was very horrible for him. He would become seriously agitated at night and pace in circles wimping. During the day he hardly responded and his eyes looked vacant and dull. We were at the point of having him pts. I remembered using the equine version on a horse and it worked to settle him in competition. So I gave it a go not really very hopefull. Within two days he was more settled. He continued to improve and has been on it now for a month and the Sundown no longer bothers him. His eyes are bright and he is now enjoying life. No longer dragging on walks and his appetite is healthy again. He is still an old dog but a normal old dog. No longer stressed and confused. No pacing and staring. I cant beleive the difference we have our dog back. He is fed the dose for a large dog although he is a labrador and med. Review: Amazing supplement to help with training! - I absolutely love this product. I was given this by my vets for my incredibly nervous rescue American Bull Dog x Staffy. She has extreme seperation anxiety and is nervous when it comes to every day normal tasks. It became such a strain on our lives and we found it impossible to train her. But after a few days of being on the medication, my dog had completely calmed down, less barking and nervousness and she's an absolute dream when out socialising with other dogs. Bare in mind this medication only works alongside strict training. They're not a quick solution. The medication clears my dogs mind enough to allow that training, if you're determined then the medication will work! ## Features - Calming Supplement for Large Dogs: Zylkene (450mg) is a calming supplement for large dogs (30 to 60kg) to help them cope with short-term challenging situations such as fireworks and social gatherings - Trusted by Professionals: UK's No. 1 Veterinary Calming Supplement, widely used and trusted by vets, behaviourists and pet owners (Kynetec market data, MAT May 2023) - Versatile Use: Suitable for challenging situations inside and outside the home so cats and dogs can feel calm wherever they are - Natural Active Ingredient: Contains alpha casozepine, a natural milk protein with clinically proven calming properties - Easy Administration: Can easily be sprinkled on to your pet's food and absorbed internally providing action for pets in and out of the home - Convenient Pack Size: Contains 20 capsules providing support for your large dog during stressful situations and challenging events ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B00K06M9QC | | Age Range Description | Adult | | Allergen Information | Allergen-Free | | Benefits | Brain Health Support | | Best Sellers Rank | 745 in Pet Supplies ( See Top 100 in Pet Supplies ) 29 in Relaxants & Anxiety Relief for Dogs | | Brand | Zylkene | | Brand Name | Zylkene | | Colour | White & Blue | | Country Of Origin | France | | Customer Reviews | 3.9 out of 5 stars 415 Reviews | | Diet Type | Gluten Free | | Diet type | Gluten Free | | Dosage Form | Capsule | | Flavour | Unflavoured | | Included Components | nil | | Item Dimensions | 6 x 6 x 17 centimetres | | Item Form | Capsule | | Item Nype Name | Relaxants & Anxiety Relief for Large Dogs | | Item Weight | 450 Milligrams | | Item form | Capsule | | Manufacturer | Vetoquinol | | Manufacturer Contact Information | Vetoquinol UK Ltd, Steadings Barn, Pury Hill Business Park, Nr Alderton, Towcester, Northamptonshire NN12 7LS | | Manufacturer Part Number | 3605874361775 | | Model Name | Zylkene | | Model Number | 3605874361775 | | Number of Items | 1 | | Primary Supplement Type | Casein | | Primary supplement type | Casein | | Product Warranty | 2 year manufacturer | | Product benefits | Brain Health Support | | Specific Uses For Product | Behaviour | | Supplement Formulation | Individual Supplement | | Unit Count | 20.0 count | ## Product Details - **Brand:** Zylkene - **Flavour:** Unflavoured - **Item form:** Capsule - **Primary supplement type:** Casein - **Product benefits:** Brain Health Support ## Images ![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 1](https://m.media-amazon.com/images/I/71hWFQgX5nL.jpg) ![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 2](https://m.media-amazon.com/images/I/71W65hGXErL.jpg) ![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 3](https://m.media-amazon.com/images/I/71tHQqd+0yL.jpg) ![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 4](https://m.media-amazon.com/images/I/71dUKTHJl5L.jpg) ![Zylkene Calming Supplements for Large Dogs (30 to 60kg) 450mg | Promotes Relaxation | Helps Pets cope with short-term challenging situations: Loud Noises | Easily administered | 20 capsules - Image 5](https://m.media-amazon.com/images/I/616wZP8AcsL.jpg) ## Available Options This product comes in different **Size** options. ## Questions & Answers **Q: What is the best time to give** A: Zylkene is suitable for both short- and long-term use. For short term use we recommend you begin administration 1 or 2 days before the predicted stressful event. For long term use, give Zylkene to your pet every day for a month then reassess their needs and continue if needed. We recommend talking to your vet if it is a long-term problem to make sure there are no underlying issues. We hope this information was useful! The Zylkene Team. **Q: Why is The packaging is all in foreign?** A: If it is a foreign supplier, I imagine the info will not be in English, I always search for UK seller. **Q: I have a 4 month old kitten is it safe to give her these please?** A: My kitten is 2 mouths old and my vet prescribed me this medication for him . Unfortunately I didn’t see any difference yet . **Q: How long does it take to work?** A: used to calm our dog before going to the groomers , started 3 days before our appointment giving 2 tablets daily . Originally prescribed by our vet and those were dosage recommended ## Customer Reviews ### ⭐⭐⭐⭐⭐ OMG I cant praise this enough *by A***T on 25 March 2026* If I could give this ten stars I would ! We have an old dog suffering from dementia. He is physically in excellent health but was suffering from severe stress and a condition named Sundown which was very horrible for him. He would become seriously agitated at night and pace in circles wimping. During the day he hardly responded and his eyes looked vacant and dull. We were at the point of having him pts. I remembered using the equine version on a horse and it worked to settle him in competition. So I gave it a go not really very hopefull. Within two days he was more settled. He continued to improve and has been on it now for a month and the Sundown no longer bothers him. His eyes are bright and he is now enjoying life. No longer dragging on walks and his appetite is healthy again. He is still an old dog but a normal old dog. No longer stressed and confused. No pacing and staring. I cant beleive the difference we have our dog back. He is fed the dose for a large dog although he is a labrador and med. ### ⭐⭐⭐⭐⭐ Amazing supplement to help with training! *by A***R on 11 August 2017* I absolutely love this product. I was given this by my vets for my incredibly nervous rescue American Bull Dog x Staffy. She has extreme seperation anxiety and is nervous when it comes to every day normal tasks. It became such a strain on our lives and we found it impossible to train her. But after a few days of being on the medication, my dog had completely calmed down, less barking and nervousness and she's an absolute dream when out socialising with other dogs. Bare in mind this medication only works alongside strict training. They're not a quick solution. The medication clears my dogs mind enough to allow that training, if you're determined then the medication will work! ### ⭐⭐⭐⭐ Nothing worked to calm my dog, He had massive ... *by P***A on 24 September 2017* Nothing worked to calm my dog, He had massive anxiety at night, tried calming spray, rescue remedy, vet prescribed antidepressants and sedatives which just made him fall over. Tried Zylkene, worked within 3 nights, very excited to be able to sleep myself so ordered loads more, sadly I think my pooch has got used to it, we now have sleep about 4 out of 7 nights which is a bonus. He is a large dog on 450mg X2 . Worth a try, expensive but anything is worth a nights sleep. ## Frequently Bought Together - Zylkene Calming Supplements for Large Dogs (15 to 60kg) 450mg | Helps ease Pet Anxiety | Helps Pets cope with short-term challenging situations | Easily administered | 20 capsules - Adaptil Calm Home Diffuser For Dogs With 30 Day Refill, Adaptil Dog Calming Plug In Pheromone Diffuser To Help Reduce Anxiety And Stress In Pet Dogs, Pet Diffuser Helps Anxious Dogs Stay Calmer --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.us/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg](https://www.desertcart.us/products/51457228-zylkene-calming-supplements-for-large-dogs-30-to-60kg-450mg) --- *Product available on Desertcart United States of America* *Store origin: US* *Last updated: 2026-08-30*