---
product_id: 428276319
title: "Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)"
brand: "designs for health"
price: "$143.93"
currency: USD
in_stock: true
reviews_count: 5
category: "Designs For Health"
url: https://www.desertcart.us/products/428276319-designs-for-health-homocysteine-supreme-methylated-b-vitamins-with-riboflavin
store_origin: US
region: United States of America
---

# Vegetarian & Non-GMO purity Methylated B vitamins for brain support Optimizes homocysteine for heart health Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)

**Brand:** designs for health
**Price:** $143.93
**Availability:** ✅ In Stock

## Summary

> 🧬 Unlock your brain & heart’s full potential with every capsule!

## Quick Answers

- **What is this?** Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) by designs for health
- **How much does it cost?** $143.93 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/428276319-designs-for-health-homocysteine-supreme-methylated-b-vitamins-with-riboflavin)

## Best For

- designs for health enthusiasts

## Why This Product

- Trusted designs for health brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Brain & Heart Synergy:** Clinically designed to support cognitive clarity and cardiovascular resilience, empowering your daily vitality.
- • **Clean & Conscious Choice:** Vegetarian, allergen-free, non-GMO, soy & gluten-free—crafted for mindful health enthusiasts.
- • **Precision Methylation Boost:** Advanced methylated B complex with L-serine & TMG ensures efficient homocysteine metabolism for peak biochemical performance.
- • **Superior Absorption Formula:** Includes bioactive methylated folate, B12, P5P B6, and riboflavin for maximum uptake and effectiveness.
- • **Practitioner-Trusted Excellence:** Top-ranked by functional medicine pros, delivering clinically-backed quality you can rely on.

## Overview

Designs for Health Homocysteine Supreme is a premium methylated B vitamin complex enhanced with L-serine and Trimethylglycine (TMG) to support efficient homocysteine metabolism. This vegetarian, non-GMO formula promotes optimal brain and cardiovascular health through superior absorption of methylated folate, B12, B6, and riboflavin. Trusted by functional medicine practitioners, it’s designed for adults seeking advanced methylation support and overall biochemical balance.

## Description

DFH Customer Favorites Visit the store DFH Customer Favorites Visit the store Shop Magnesium Supplements Visit the store Shop Magnesium Supplements

Review: Homocysteine was requested by my Doctor. The order came in a timely fashion. - Very good product, delivery was quick. The product was what was suggested by my Doctor.
Review: Life / Brain Changer - I have tried 3 different products - I even tried “unmethylated” B12/folate etc. I do carry the MTHFR gene and have high homocysteine. THIS PRODUCT…. Not the others works for me. Though 2 caps is recommended and the dosage on the label is according to that - I can only do 1/4 of ONE capsule a day, but the difference in my life is night and day now. Im 67 and have lived most of my life with migraines, anxiety, depression and in the last couple of years I have been increasingly worried about my brain. My mother was diagnosed with Alzheimer’s at my age and I was mentally feeling worse and worse. I have recently come through a terrible tragedy - the violent death of my 40 year old son. After this happened I was significantly different in my brain. I could not shake the blackness (not just depression) I would wake in the morning and this horrible feeling was with me all day - consistently - over time. I put it down to grief. The first 3 days on this product I felt like I was 20 again. I remembered how I used to have hope and just feel “normal” like this. I realized quickly that I could not take 2 caps a day - I was literally flying mentally and did not sleep the first two nights. Over time I figured out my dosage and I am still in grief but I live every day ‘grounded’ and stable - I have energy and my brain fog is literally gone as is my black feeling in my brain. Anxiety and fear are just not there. I encourage everyone to at least get tested for the MTHFR gene and homocysteine - these tests are now available online without the need for a prescription (at least in California) - easy to find out! God bless you all - I am so thankful to the Lord for this answer to prayer.

## Features

- Methylation Support - A modified methylated B complex with L-serine and TMG, which are known to facilitate the efficient metabolism of homocysteine and normal methylation
- Promotes Heart & Brain Health - An optimally functioning homocysteine pathway plays a role in biochemical reactions, such as detoxification, healthy immune support, ideal joint and cartilage structure, brain health and cardiovascular health
- Premium B Vitamins & TMG for Superior Absorption - Supplies a methylated folate and B12 supplement, along with P5P vitamin B6 and riboflavin. Includes Trimethylglycine to support normal methylation
- Vegetarian & Non-GMO - Vegetarian-friendly and made without soy, gluten, GMOs or soy. Take 2 capsules per day with meals or as directed by your health-care practitioner
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00DJE2WP0 |
| Age Range Description | Adult |
| Allergen Information | Allergen-Free |
| Best Sellers Rank | #63,628 in Health ( See Top 100 in Health ) #1,650 in Multiple Vitamin-Mineral Combination Supplements |
| Brand | designs for health |
| Brand Name | designs for health |
| Customer Reviews | 4.6 out of 5 stars 297 Reviews |
| Diet Type | Vegetarian |
| Diet type | Vegetarian |
| Dosage Form | Capsule |
| Flavor | Unflavored |
| Flavour | Unflavored |
| Item Dimensions | 5.6 x 5.6 x 10.2 centimeters |
| Item Form | Capsule |
| Item Weight | 0.04 Ounces |
| Item form | Capsule |
| Manufacturer | Designs for Health |
| Manufacturer Part Number | HYS060-AZ |
| Material Type Free | en_AE |
| Number of Items | 1 |
| Primary Supplement Type | Methylation Support Capsules |
| Primary supplement type | Methylation Support Capsules |
| Product Benefits | metabolism_improvement, energy_management, antioxidant |
| Product benefits | metabolism_improvement, energy_management, antioxidant |
| Special Ingredients | B Vitamins, TMG, L-serine |
| Specific Uses For Product | Laboratory |
| Unit Count | 1.0 Count |

## Product Details

- **Brand:** designs for health
- **Diet type:** Vegetarian
- **Flavour:** Unflavored
- **Item form:** Capsule
- **Primary supplement type:** Methylation Support Capsules

## Images

![Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) - Image 1](https://m.media-amazon.com/images/I/71vlsNh43hL.jpg)
![Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) - Image 2](https://m.media-amazon.com/images/I/61ShKg2b3pL.jpg)
![Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) - Image 3](https://m.media-amazon.com/images/I/715Q5ABQHRL.jpg)
![Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) - Image 4](https://m.media-amazon.com/images/I/71wC7+6ZzOL.jpg)
![Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) - Image 5](https://m.media-amazon.com/images/I/71EyZlxXxKL.jpg)

## Questions & Answers

**Q: Curious why NAC was removed from the ingredients.**
A: Not just NAC, but zinc,B2, serine and chloline dihydrohen citrate

**Q: Does the Homocysteine Supreme contain turmeric?**
A: No, it contains riboflavin, vit. B-6, folate,vit. B-12, trimethylglycine, and L-serine. additional ingredients are cellulose/microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, and silicon dioxide

**Q: Designs for health is the product manufacturer - who is the seller on Amazon?**
A: It's sold by the Designs for Health store on Amazon.

**Q: Does this product contain Bromelain in it?**
A: I just checked the label and I don't see Bromelain mentioned anywhere on the label. Hope this helps you.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Homocysteine was requested by my Doctor. The order came in a timely fashion.
*by D***N on 3 February 2026*

Very good product, delivery was quick. The product was what was suggested by my Doctor.

### ⭐⭐⭐⭐⭐ Life / Brain Changer
*by W***Y on 6 May 2026*

I have tried 3 different products - I even tried “unmethylated” B12/folate etc. I do carry the MTHFR gene and have high homocysteine. THIS PRODUCT…. Not the others works for me. Though 2 caps is recommended and the dosage on the label is according to that - I can only do 1/4 of ONE capsule a day, but the difference in my life is night and day now. Im 67 and have lived most of my life with migraines, anxiety, depression and in the last couple of years I have been increasingly worried about my brain. My mother was diagnosed with Alzheimer’s at my age and I was mentally feeling worse and worse. I have recently come through a terrible tragedy - the violent death of my 40 year old son. After this happened I was significantly different in my brain. I could not shake the blackness (not just depression) I would wake in the morning and this horrible feeling was with me all day - consistently - over time. I put it down to grief. The first 3 days on this product I felt like I was 20 again. I remembered how I used to have hope and just feel “normal” like this. I realized quickly that I could not take 2 caps a day - I was literally flying mentally and did not sleep the first two nights. Over time I figured out my dosage and I am still in grief but I live every day ‘grounded’ and stable - I have energy and my brain fog is literally gone as is my black feeling in my brain. Anxiety and fear are just not there. I encourage everyone to at least get tested for the MTHFR gene and homocysteine - these tests are now available online without the need for a prescription (at least in California) - easy to find out! God bless you all - I am so thankful to the Lord for this answer to prayer.

### ⭐⭐⭐⭐⭐ Homocysteine Supreme
*by G***Y on 6 July 2026*

Great Supplement recommended by my wellness physician.

## Frequently Bought Together

- Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules)
- Designs for Health Vitamin D Supreme - Vitamin D 5000 IU with 2000mcg Vitamin K as MK4 for Bone Health, Heart Health & Immune Support - Vitamin D3 Enhanced with GG Supplement (60 Capsules)
- Designs for Health N-Acetyl-L-Cysteine - 900mg NAC, Antioxidant Glutathione Precursor - Detox + Workout Recovery Support - Non-GMO + Gluten Free Supplement (120 Capsules)

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-07-22*