---
product_id: 329440482
title: "S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz"
brand: "douxo"
price: "$52.04"
currency: USD
in_stock: true
reviews_count: 13
category: "Douxo"
url: https://www.desertcart.us/products/329440482-s3-pyo-medicated-dog-shampoo-with-3-chlorhexidine-for-dogs
store_origin: US
region: United States of America
---

# 0.5% Ophytrium natural skin barrier support 6.7 fl. oz. concentrated formula lasts long 3% Chlorhexidine antiseptic power S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz

**Brand:** douxo
**Price:** $52.04
**Availability:** ✅ In Stock

## Summary

> ✨ Elevate your pet’s skin health game with vet-trusted science! 🐶🐱

## Quick Answers

- **What is this?** S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz by douxo
- **How much does it cost?** $52.04 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/329440482-s3-pyo-medicated-dog-shampoo-with-3-chlorhexidine-for-dogs)

## Best For

- douxo enthusiasts

## Why This Product

- Trusted douxo brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Pure & Gentle Formula:** Free from soaps, sulfates, parabens, dyes, and nanoparticles for hypoallergenic, irritation-free care.
- • **Smart, Sustainable Use:** Thick, easy-to-suds formula with a leak-proof pump—small amount goes a long way, saving you money.
- • **Hydrates & Detangles Fur:** Infused with Ophytrium to moisturize skin and leave coats soft, shiny, and tangle-free.
- • **Rapid Skin & Coat Revival:** Clinically proven to reduce yeast and soothe irritated skin within 7 days—see the transformation fast.
- • **Vet-Approved Infection Defense:** Trusted #1 non-prescription antiseptic shampoo recommended by U.S. veterinarians for dogs & cats.

## Overview

Douxo S3 Pyo Shampoo combines 3% Chlorhexidine antiseptic with 0.5% Ophytrium, a natural skin barrier booster, to effectively treat bacterial and yeast skin infections in dogs and cats. This hypoallergenic, soap- and sulfate-free formula soothes irritation, hydrates skin, and detangles fur, delivering visible improvements in just 7 days. Recommended by U.S. veterinarians and designed for lasting use with a convenient pump, it’s the go-to solution for managing inflammatory dermatological conditions while keeping your pet’s coat soft, healthy, and fresh.

## Description

DOUXO S3 PYO Dog Shampoo helps support dogs with bacterial and yeast skin infections that are responsive to chlorhexidine by providing antiseptic cleansing and hydrating the skin. Formulated with chlorhexidine. Vet-recommended and free from soaps, sulfates, parabens, colorants, nanoparticles, and phthalates. For best results, pair with DOUXO S3 PYO Dog Mousse and Wipes.

Review: Miracle in a bottle! - My senior French Bulldog recently developed very dry, brittle fur that felt like hay/straw and was shedding like crazy. Her skin was also VERY greasy, smelly, and slightly bumpy, even just a week after bathing. She also had dried skin flakes that looked like dandruff. In just one wash her fur was noticeably soft and conditioned; her skin was supple and moisturized; and the best part — no more shedding, dandruff, greasy skin or odor! The bumps on her skin subsided and were no longer inflamed. She also smells amazing! A light coconut scent that is soft and subtle and not overwhelming. We used to use Douxo S3 PYO 10 yrs ago when she was a puppy but stopped after they changed formulas, afraid that it wouldn’t be the same. Boy I wish we hadn’t. For the first time ever, my senior puppy had zoomies after her bath! This will be our go-to shampoo for flare-ups from now on!
Review: Amazing product, good stuff! - My Maltese has always had skin allergies, but as he’s gotten older it has gotten worse, especially with yeast on his skin. This shampoo has been the best product I have ever used (I have tried several) and I am going to also let my vet know about it. It took all the stickies off his fur and skin and made his fur shiny and soft again. He’s no longer scratching himself to a point where he makes his skin bleed and he looks much more comfortable.. Amazing product!

## Features

- CLINICALLY PROVEN RESULTS: DOUXO S3 is proven to show results in as soon as 7 days.
- ANTISEPTIC CHLORHEXIDINE DOG SHAMPOO FOR YEAST AND BACTERIAL SKIN INFECTIONS: Formulated for dogs with bacterial or yeast skin infections – DOUXO S3 PYO chlorhexidine dog shampoo provides an antiseptic cleansing while hydrating the skin.
- #1 TOPICAL BRAND RECOMMENDED BY VETS: Confirmed by veterinary and scientific expertise. DOUXO provides the best and the safest care for your pet.
- ENRICHED WITH OPHYTRIUM: Contains 0.5% Ophytrium, a purified, natural ingredient that helps soothe irritated skin and support skin hydration.
- FREE FROM soaps, sulphates, parabens, colorants, nanoparticles, and phthalates.
- COMPLETE SKINCARE TREATMENT ROUTINE: For best results, pair with DOUXO S3 PYO Dog Mousse and Wipes — a complete solution for dogs with bacterial or yeast skin infections. 90% of pet owners were satisfied with DOUXO S3 routine.

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0947674MT |
| Allergen Information | Hypoallergenic |
| Best Sellers Rank | #400 in Pet Supplies ( See Top 100 in Pet Supplies ) #3 in Dog Shampoos |
| Brand | Douxo |
| Brand Name | Douxo |
| Customer Reviews | 4.7 out of 5 stars 7,549 Reviews |
| Included Components | Shampoo |
| Item Form | Liquid |
| Item Type Name | Shampoos & Conditioners |
| Item Weight | 6.7 Ounces |
| Liquid Volume | 6.7 Fluid Ounces |
| Manufacturer | Douxo S3 |
| Manufacturer Part Number | D98410M |
| Material Type Free | Paraben Free,Sulfate Free |
| Model Number | D98410M |
| Pet Type | Cat, Dog |
| Product Benefits | Soothing,Moisturizing,Detangle |
| Recommended Uses For Product | For Bacterial or Yeast Skin Infections For Dogs and Cats |
| Scent | Coconut, Vanilla |
| Scent Name | Coconut, Vanilla |
| Special Ingredients | ophytrium |
| Target Species | dog, cat |
| UPC | 850002593426 |
| Unit Count | 1 Count |

## Product Details

- **Brand:** Douxo
- **Material Type Free:** Paraben Free,Sulfate Free
- **Product Benefits:** Soothing,Moisturizing,Detangle
- **Recommended Uses For Product:** For Bacterial or Yeast Skin Infections For Dogs and Cats
- **Scent:** Coconut, Vanilla

## Images

![S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz - Image 1](https://m.media-amazon.com/images/I/61zoiSKTJQL.jpg)
![S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz - Image 2](https://m.media-amazon.com/images/I/81ENkKOT82L.jpg)
![S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz - Image 3](https://m.media-amazon.com/images/I/715MS9rlT3L.jpg)
![S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz - Image 4](https://m.media-amazon.com/images/I/81ElXdFnn9L.jpg)
![S3 PYO Medicated Dog Shampoo with 3% Chlorhexidine for Dogs – Antibacterial & Antiseptic Yeast Infection Treatment For Dogs & Cats, Clinically Proven, 6.7 fl oz - Image 5](https://m.media-amazon.com/images/I/713uvxxLqjL.jpg)

## Available Options

This product comes in different **Size** options.

## Questions & Answers

**Q: Is there a prescription only version of this shampoo or is this the only one?  My vet prescribed this for my dog and it is less expensive on Amazon**
A: You don't need a prescription! Same thing happened to me.  Go with Amazon

**Q: What do I do if the bottle leaked the shampoo everywhere?**
A: Wipe it up and return for refund.

**Q: Is this antiseptic and antifungal? The bottle in the first picture only says antiseptic**
A: The bottle I bought clearly says antiseptic and antifungal shampoo.  So I would have to say you might have bought wrong one if you wanted both.  Maybe Amazon will allow you to return and rebuy the other one.  Otherwise, this stuff worked well for my dog to give her some relief from all her skin issues.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Miracle in a bottle!
*by _***_ on March 25, 2026*

My senior French Bulldog recently developed very dry, brittle fur that felt like hay/straw and was shedding like crazy. Her skin was also VERY greasy, smelly, and slightly bumpy, even just a week after bathing. She also had dried skin flakes that looked like dandruff. In just one wash her fur was noticeably soft and conditioned; her skin was supple and moisturized; and the best part — no more shedding, dandruff, greasy skin or odor! The bumps on her skin subsided and were no longer inflamed. She also smells amazing! A light coconut scent that is soft and subtle and not overwhelming. We used to use Douxo S3 PYO 10 yrs ago when she was a puppy but stopped after they changed formulas, afraid that it wouldn’t be the same. Boy I wish we hadn’t. For the first time ever, my senior puppy had zoomies after her bath! This will be our go-to shampoo for flare-ups from now on!

### ⭐⭐⭐⭐⭐ Amazing product, good stuff!
*by A***. on April 18, 2026*

My Maltese has always had skin allergies, but as he’s gotten older it has gotten worse, especially with yeast on his skin. This shampoo has been the best product I have ever used (I have tried several) and I am going to also let my vet know about it. It took all the stickies off his fur and skin and made his fur shiny and soft again. He’s no longer scratching himself to a point where he makes his skin bleed and he looks much more comfortable.. Amazing product!

### ⭐⭐⭐⭐⭐ 5 Stars - HIGHLY Recommend! Works Amazing for Allergies!
*by H***R on September 15, 2025*

Hands down the best dog shampoo I've ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he's allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I'm averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I'll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent! The smell is really great as well, it's a lighter scent, I don't smell any chemicals or any of the normal medicated smell at all & it's light enough you can smell it on your pup if you're up close, but otherwise it's not noticeable. The formula is decently thick, it's not runny at all, but it suds up so great as well - another huge thing most medicated shampoos don't do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it's so easy to suds up, that you don't need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that's about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don't have to worry about it leaking, we transport it every weekend to our MIL's house, and I just throw it in the bag, never leaked before, you don't have to worry about it. I can't recommend this shampoo enough or stress how well its been working for our 4 dogs!

## Frequently Bought Together

- Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL)
- Douxo S3 Pyo Mousse, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, for Bacterial or Yeast Skin Infections, for Dogs, 5.1 fl. oz. (150mL)
- Douxo S3 Pyo Pads, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 30 Pads

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-05-20*