---
product_id: 25717794
title: "Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Building DHA Baby Formula, Powder 20.5 Oz Tub"
brand: "enfamil"
price: "$121.67"
currency: USD
in_stock: true
reviews_count: 8
category: "Enfamil"
url: https://www.desertcart.us/products/25717794-enfamil-optimum-enspire-our-closest-formula-to-breast-milk-immune
store_origin: US
region: United States of America
---

# Closest to breast milk Brain-building DHA Immune-supporting lactoferrin Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Building DHA Baby Formula, Powder 20.5 Oz Tub

**Brand:** enfamil
**Price:** $121.67
**Availability:** ✅ In Stock

## Summary

> 🍼 Nourish brilliance & immunity—because your baby deserves the best start!

## Quick Answers

- **What is this?** Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Building DHA Baby Formula, Powder 20.5 Oz Tub by enfamil
- **How much does it cost?** $121.67 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/25717794-enfamil-optimum-enspire-our-closest-formula-to-breast-milk-immune)

## Best For

- enfamil enthusiasts

## Why This Product

- Trusted enfamil brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Dual Prebiotic Power:** 2'-FL & LnNT HMOs nourish baby’s immune system naturally
- • **Breast Milk’s Best Ally:** First formula with lactoferrin, mirroring colostrum’s immune power
- • **Pure & Trusted Ingredients:** Non-GMO, no artificial hormones, colors, or flavors—clean nutrition parents demand
- • **Seamless Feeding Flexibility:** Perfect for combo feeding or full-time formula with pediatrician trust
- • **Smart Nutrition for Growing Minds:** Clinically-tested DHA to boost brain development

## Overview

Enfamil Optimum is a premium infant formula designed to closely replicate breast milk by including lactoferrin, dual HMOs (2'-FL & LnNT), and brain-building DHA. It supports immune health and cognitive development with clinically-tested, non-GMO ingredients free from artificial additives. Trusted by pediatricians and parents alike, it offers complete daily nutrition in a convenient powder tub for infants up to 12 months, ideal for both exclusive formula feeding and breastfeeding supplementation.

## Description

Give your baby a great start with Enfamil Optimum—our most advanced formula designed to support immune health and brain development, inspired by the composition of breast milk. Enfamil Optimum, formerly known as Enfamil Enspire Optimum, is our closest baby formula to breast milk. It has lactoferrin, a key immune-supporting protein also found in colostrum and breast milk. It also has a dual HMO blend—2'-FL and LnNT—two of the most abundant human milk oligosaccharides (HMOs) naturally found in breast milk, to help nourish your baby’s immune system. It has brain-building DHA and is made without artificial growth hormones*, artificial colors, or flavors, Enfamil Optimum is a non-GMO† option for parents seeking premium infant nutrition through 12 months of age. Whether you're combo feeding or transitioning from breastfeeding, this formula offers both peace of mind and convenience for growing families. Join Enfamil Family Beginnings to earn rewards with every purchase and access exclusive benefits and support. SNAP eligible.

Review: Quest to find the right formula for 4m old twins - UPDATE (below ----- is my previous review) It's been almost a month since my previous review (4stars -1due to high price) and I wanted to come back for an update. I changed it to 5 stars because of an amazing story. Till now, the younger twin has been on 1/2 Gentlease and 1/2 Enspire VS The older twin 100% Enspire for about 5 weeks now. When I wrote the previous revie, the younger twin has already turned from back to his tummy (he was on 100%Gentlease and the older one had no intention of trying to turn (he was on Gerber Good Start Gentle+Similac Advanced). About 3 weeks into using Enspire, one day, the older twin managed to turn to the left and right and rolled over and over and over, all in one day and I have not been trying to teach him to do any of these! The younger twin, as of today, could roll but he still only turn from back to tummy from his left and he has trouble getting his arm out from his belly. I can't say if the get it all in one day miracle of the older twin was because he drank more Enspire than his younger brother, it probably can be just be a coincidence. But we were just so shocked by this and now we can't wait to finish the remaining 3 cans of Gentlease and have the younger twin on 100% Enspire. ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- I have twin boys born at 36 weeks, June 1, 2016, 5.5lb each. They are formula fed exclusively from birth. We started with Similac Advanced ready to feed (what the hospital gave us), one of the boys (Baby A) is fine with it but the other (Baby B) gets constipated and his tummy seem to be very uncomfortable after 2 weeks of use on Similac. Then I switched baby B to Enfamil Gentlease ready to feed, it worked like a miracle! After first feeding, he was happy and calm and he drank it quickly with pleasure! Baby A didn't like Gentlease at all so I kept him on Advanced. Later, I read some reviews on desertcart and some reviewers stated that Gentlease has corn starch solids which may be a bad ingredient for babies, so I tried Gerber Gentle Good Start ready to feed. Baby B occasionally drink Gerber but it was obvious he prefers the taste Gentlease a lot more, so I had to keep him on Gentlease. Baby A drank Gerber Gentle almost all the time, but he still prefers Similac Advanced (drinks faster on Similac). About a week ago, I learned about Enfamil Enspire and decided to give it a try! Baby A LOOOOOOVES it as much as he loves Similac Advanced. Baby B still prefers Gentlease but I have him on 1/2 Enspire and 1/2 Gentlease and he's fine with it. I don't mind the extra cost because I want the best for my babies, to make it up to them that I'm not able to breastfeed them at all. I don't know if Enspire is really better to worth the extra cost but their advertised statement "our closest to breast milk" is just too powerful. Yes, I'm a sucker for advertisement and other people's reviews. My babies have been on 1) Similac Advanced ready to feed (from birth at hospital) 2) Enfamil Gentlease ready to feed & powder (for baby B, easy to mix, not foamy if you shake the bottle to mix, excellent bowl movement, less spit up/vomiting) 3) Similac Neosure ready to feed for premature babies (2 bottles of 32oz ready to feed) - it made both of them constipated and uncomfortable. 4) Gerber Good Start Gentle ready to feed (somehow both of them don't like it, I think it's the taste) 5) Enfamil Enspire powder ( CAUTION: VERY FOAMY if you shake the bottle, I use a chopstick to stir it instead to avoid the foam of tiny bubbles) (EXCELLENT, REGULAR POOP, NO PROJECTILE VOMITING SINCE I started on this a week ago, BABY B had problem keeping in Similac and Gerber, he had projectile vomit about once to twice a week, which is not that bad , but still scary!) I know it's crazy that they have already tried all these different formulas, but they gained weight really well, they are both at 15lb. now! It's amazing! I have only started the Enspire a week ago so I don't know if it will continue to help them thrive at gaining weight. I will come back to update in a month or two. I'm determined at this point to have them both stay on this formula. (eventually changing 1/2 Gentlease 1/2 Enspire to Enspire exclusively if Baby B would respond well to it)
Review: If you can afford it this is the winner. - Let me start by saying this formula is likely not the "best tasting" one out there. "Best tasting" when it comes to food is often the worst when it comes to nutrition. If you're concerned about taste/smell this formula is probably not for you. I personally am un-bothered by the smell and only read the nutritional label when making my choice. If you're concerned about the quality of ingredients, don't want an obese child, and want to give your kid the best nutritional formula the US has to offer.... This product is for you. Secondly, I highly recommend ordering the refill packs on desertcart. Get your initial plastic tub from the grocery store then refill it the $55 box from desertcart. It's cheaper and you don't have to worry about seals being broken. This stuff is expensive.... But it helped develop my thriving 10-month-old who is talking, laughing, smiling, communicating, and hitting all of her physical milestones with ease. She was born 5 weeks early and we worried about her mental development. She was tiny and behind other babies at first in her milestones. Since my wife breastfed and could never keep up, this was initially recommended by our pediatrician to help supplement and eventually transition from breast milk. The lactoferrin and MFGM are the special ingredients along with lactose being it's only sweetener instead of corn syrup. The MFGM makes a big difference in mental development while the lactoferrin helps develop a healthy gut (which attributes to the loads of parents saying this is the only thing their little ones can keep down). These are the only two ingredients that set it apart from traditional formulas... and they truly make a world of difference. This stuff is great. If it is just a little too expensive check out Enfamil NeuroPro... Which is basically the same thing just minus the Lactoferrin (it still contains the brain developing MFGM). Hopefully next time our next child decides to stay in the belly full-term, the breastfeeding starts off on the right foot and continues through one year. If not, I won't think twice before using Enfamil Enspire again. It's truly a no-brainer and we are so grateful to Enfamil for developing this incredible formula.

## Features

- NEW LOOK, SAME PREMIUM NUTRITION: Previously known as Enspire Optimum, Enfamil Optimum Baby Formula now has a refreshed look and name while offering the same trusted infant nutrition parents rely on
- OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading baby formula to include lactoferrin, a key immune-supporting protein found in colostrum and breastmilk
- SUPPORTS IMMUNE & BRAIN DEVELOPMENT: This premium formula includes lactoferrin, a dual prebiotic blend (2'FL & LnNT), and brain-building DHA—all clinically-tested ingredients
- COMPLETE NUTRITION FOR DAILY FEEDINGS: A great choice for everyday formula use, this 30 oz tub of Enfamil Optimum provides complete nutrition in a convenient powder format—perfect for full-time feeding or supplementing breast milk
- TRUSTED NUTRITION FOR COMBO FEEDING: With key nutrients for growing babies, Enfamil Optimum gives parents the flexibility to supplement breastfeeding with our closest formula to breast milk
- NO ARTIFICIAL ADDITIVES & NON-GMO: Has clinically-tested, non-GMO ingredients. Free from artificial growth hormones, colors, and flavors. Enfamil Optimum does not contain high fructose corn syrup and is made with milk sourced from the United States.
- PEDIATRICIAN & PARENT TRUSTED: Enfamil is the #1 trusted infant formula brand by pediatricians* and parents, making Optimum baby formula a reliable choice for growing families.Optimum is premium baby formula for infants through 12 months of age
- JOIN ENFAMIL FAMILY BEGINNINGS & EARN REWARDS: Sign up for Enfamil Family Beginnings to enjoy exclusive savings, expert tips, and personalized support—plus earn rewards with every eligible purchase.
- CHOOSE A CASE PACK FOR ADDED CONVENIENCE: Stock up with a case pack of Enfamil formula to help ensure you’re always prepared—ideal for regular feedings and busy routines

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B01ASIEJPA |
| Age Range (Description) | Infant |
| Age Range Description | Infant |
| Best Sellers Rank | #2,977 in Baby ( See Top 100 in Baby ) #39 in Powder Baby Formula |
| Brand | Enfamil |
| Brand Name | Enfamil |
| Container Type | Tub |
| Customer Reviews | 4.7 out of 5 stars 3,200 Reviews |
| Diet Type | Kosher |
| Each Unit Count | 1 |
| Global Trade Identification Number | 00300875117484 |
| Item Form | Powder |
| Item Weight | 1.28 Pounds |
| Manufacturer | Mead Johnson Nutrition |
| Model Number | 157401 |
| Number of Items | 1 |
| Package Information | Tub |
| Part Number | 157401 |
| Size | 20.5 Ounce (Pack of 1) |
| UPC | 300875117484 |
| Unit Count | 20.5 Ounce |

## Product Details

- **Age Range (Description):** Infant
- **Brand:** Enfamil
- **Item Form:** Powder
- **Item Weight:** 1.28 Pounds
- **Size:** 20.5 Ounce (Pack of 1)

## Images

![Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Building DHA Baby Formula, Powder 20.5 Oz Tub - Image 1](https://m.media-amazon.com/images/I/81kyX5jx3-L.jpg)

## Available Options

This product comes in different **Size, Style** options.

## Questions & Answers

**Q: How many scoops are in a 20.5oz can?**
A: 66 scoops, which makes about 145 oz of prepared formula. It makes about 7 prepared oz of liquid formula per oz of powder if you want to compare to other sizes.

**Q: Does this contain ARA?**
A: Enspire has 34 milligrams (mg) of ARA per 100 Calories (or 5 fluid ounces when it is mixed according to label directions).

**Q: Is this supplier an authorized dealer? is it the actual enfamil manufacturer? or is it some third party?**
A: To my understanding is an authorized dealer, because it's indicated ship and sold by Amazon in the product description.  And I don't find any problem from products.  All my baby's formula powder are purchased from Amazon.

**Q: Does this make their spit up stain clothing?**
A: I haven't had any issues with staining from this formula.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Quest to find the right formula for 4m old twins
*by K***N on October 6, 2016*

UPDATE (below ----- is my previous review) It's been almost a month since my previous review (4stars -1due to high price) and I wanted to come back for an update. I changed it to 5 stars because of an amazing story. Till now, the younger twin has been on 1/2 Gentlease and 1/2 Enspire VS The older twin 100% Enspire for about 5 weeks now. When I wrote the previous revie, the younger twin has already turned from back to his tummy (he was on 100%Gentlease and the older one had no intention of trying to turn (he was on Gerber Good Start Gentle+Similac Advanced). About 3 weeks into using Enspire, one day, the older twin managed to turn to the left and right and rolled over and over and over, all in one day and I have not been trying to teach him to do any of these! The younger twin, as of today, could roll but he still only turn from back to tummy from his left and he has trouble getting his arm out from his belly. I can't say if the get it all in one day miracle of the older twin was because he drank more Enspire than his younger brother, it probably can be just be a coincidence. But we were just so shocked by this and now we can't wait to finish the remaining 3 cans of Gentlease and have the younger twin on 100% Enspire. ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- I have twin boys born at 36 weeks, June 1, 2016, 5.5lb each. They are formula fed exclusively from birth. We started with Similac Advanced ready to feed (what the hospital gave us), one of the boys (Baby A) is fine with it but the other (Baby B) gets constipated and his tummy seem to be very uncomfortable after 2 weeks of use on Similac. Then I switched baby B to Enfamil Gentlease ready to feed, it worked like a miracle! After first feeding, he was happy and calm and he drank it quickly with pleasure! Baby A didn't like Gentlease at all so I kept him on Advanced. Later, I read some reviews on Amazon and some reviewers stated that Gentlease has corn starch solids which may be a bad ingredient for babies, so I tried Gerber Gentle Good Start ready to feed. Baby B occasionally drink Gerber but it was obvious he prefers the taste Gentlease a lot more, so I had to keep him on Gentlease. Baby A drank Gerber Gentle almost all the time, but he still prefers Similac Advanced (drinks faster on Similac). About a week ago, I learned about Enfamil Enspire and decided to give it a try! Baby A LOOOOOOVES it as much as he loves Similac Advanced. Baby B still prefers Gentlease but I have him on 1/2 Enspire and 1/2 Gentlease and he's fine with it. I don't mind the extra cost because I want the best for my babies, to make it up to them that I'm not able to breastfeed them at all. I don't know if Enspire is really better to worth the extra cost but their advertised statement "our closest to breast milk" is just too powerful. Yes, I'm a sucker for advertisement and other people's reviews. My babies have been on 1) Similac Advanced ready to feed (from birth at hospital) 2) Enfamil Gentlease ready to feed & powder (for baby B, easy to mix, not foamy if you shake the bottle to mix, excellent bowl movement, less spit up/vomiting) 3) Similac Neosure ready to feed for premature babies (2 bottles of 32oz ready to feed) - it made both of them constipated and uncomfortable. 4) Gerber Good Start Gentle ready to feed (somehow both of them don't like it, I think it's the taste) 5) Enfamil Enspire powder ( CAUTION: VERY FOAMY if you shake the bottle, I use a chopstick to stir it instead to avoid the foam of tiny bubbles) (EXCELLENT, REGULAR POOP, NO PROJECTILE VOMITING SINCE I started on this a week ago, BABY B had problem keeping in Similac and Gerber, he had projectile vomit about once to twice a week, which is not that bad , but still scary!) I know it's crazy that they have already tried all these different formulas, but they gained weight really well, they are both at 15lb. now! It's amazing! I have only started the Enspire a week ago so I don't know if it will continue to help them thrive at gaining weight. I will come back to update in a month or two. I'm determined at this point to have them both stay on this formula. (eventually changing 1/2 Gentlease 1/2 Enspire to Enspire exclusively if Baby B would respond well to it)

### ⭐⭐⭐⭐⭐ If you can afford it this is the winner.
*by J***T on May 10, 2022*

Let me start by saying this formula is likely not the "best tasting" one out there. "Best tasting" when it comes to food is often the worst when it comes to nutrition. If you're concerned about taste/smell this formula is probably not for you. I personally am un-bothered by the smell and only read the nutritional label when making my choice. If you're concerned about the quality of ingredients, don't want an obese child, and want to give your kid the best nutritional formula the US has to offer.... This product is for you. Secondly, I highly recommend ordering the refill packs on Amazon. Get your initial plastic tub from the grocery store then refill it the $55 box from Amazon. It's cheaper and you don't have to worry about seals being broken. This stuff is expensive.... But it helped develop my thriving 10-month-old who is talking, laughing, smiling, communicating, and hitting all of her physical milestones with ease. She was born 5 weeks early and we worried about her mental development. She was tiny and behind other babies at first in her milestones. Since my wife breastfed and could never keep up, this was initially recommended by our pediatrician to help supplement and eventually transition from breast milk. The lactoferrin and MFGM are the special ingredients along with lactose being it's only sweetener instead of corn syrup. The MFGM makes a big difference in mental development while the lactoferrin helps develop a healthy gut (which attributes to the loads of parents saying this is the only thing their little ones can keep down). These are the only two ingredients that set it apart from traditional formulas... and they truly make a world of difference. This stuff is great. If it is just a little too expensive check out Enfamil NeuroPro... Which is basically the same thing just minus the Lactoferrin (it still contains the brain developing MFGM). Hopefully next time our next child decides to stay in the belly full-term, the breastfeeding starts off on the right foot and continues through one year. If not, I won't think twice before using Enfamil Enspire again. It's truly a no-brainer and we are so grateful to Enfamil for developing this incredible formula.

### ⭐⭐⭐⭐⭐ Expensive but worth it
*by D***A on December 11, 2020*

My little one likes this formula. I like how it does not have high fructose corn syrup in the ingredients. I really read the ingredients. She has been on this since birth and is now 6 months. No stomach issues. Very little spit up. It doesn't leave her gassy. I believe it's a better quality formula. It is expensive I will say that. It helps that enfamil sends coupons in the mail. $10 off really helps. I bought this formula for an awesome amazon deal. I was extremely happy I bought 3. The packaging is nice but I don't buy something based on that. I wasn't able to breastfeed my baby and this was a good alternative for us. It mixes well. Each container has been fresh and no issues. It comes in a sealed bag in the sealed container. Easy directions on how to mix (ounces of nursery water to scoops of formula). I use nursery water to mix. No issues warming formula. My daughter likes hers warm. No constipation with this formula. When she was a baby she was every other day. Now at six months she's everyday or twice with baby food. I really wish it wasn't so expensive to get high quality formula, but it is what it is. You can also contact enfamil and have them send you coupons. There are a lot of formula groups on facebook. Lots of coupon trading. Again, if your a mom that couldn't breastfeed this was a great formula. They also have the gentle version. I never had to use that. I'm happy with formula and will continue to buy

## Frequently Bought Together

- Enfamil Optimum Baby Formula, Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin also found in Breast Milk, Brain-Building DHA, 20.5 Oz
- Enfamil NeuroPro Baby Formula, MFGM* 5-Year Benefit, Expert-Recommended Brain-Building Omega-3 DHA, Exclusive Immune Supporting HuMO6 Blend, Infant Formula Powder, Baby Milk, 20.7 Oz
- Pampers Baby Diapers - Swaddlers - Size 0, 140 Count, Ultra Absorbent Disposable Newborn Diaper

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-07-12*