---
product_id: 253690400
title: "Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules"
brand: "thorne"
price: "$138.09"
currency: USD
in_stock: true
reviews_count: 5
category: "Thorne"
url: https://www.desertcart.us/products/253690400-methyl-guard-plus-active-folate-5-mthf-with-vitamins-b2
store_origin: US
region: United States of America
---

# Gluten-, dairy-, soy-free clean formula Active folate (5-MTHF) for superior methylation Supports healthy homocysteine & cardiovascular health Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules

**Brand:** thorne
**Price:** $138.09
**Availability:** ✅ In Stock

## Summary

> 🧬 Elevate your wellness game with science-backed methylation mastery!

## Quick Answers

- **What is this?** Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules by thorne
- **How much does it cost?** $138.09 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/253690400-methyl-guard-plus-active-folate-5-mthf-with-vitamins-b2)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Long-Lasting Value:** One capsule daily delivers a 3-month supply of premium methylation support.
- • **Cardio-Confidence Boost:** Maintain heart health with nutrients that naturally regulate homocysteine levels.
- • **Clean & Allergy-Friendly:** Formulated free from gluten, dairy, soy, and common allergens—perfect for sensitive lifestyles.
- • **Clinically Trusted Formula:** Backed by Mayo Clinic collaboration and elite pro & Olympic team endorsements.
- • **Precision Methylation Support:** Harness the power of active folate and B-vitamins for optimized gene expression and detox pathways.

## Overview

THORNE Methyl-Guard Plus combines active folate (5-MTHF) with bioavailable vitamins B2, B6, and B12 to support healthy methylation and maintain optimal homocysteine levels, promoting cardiovascular health. This gluten-, dairy-, and soy-free formula is trusted by professional athletes and developed in collaboration with Mayo Clinic, offering a clean, effective daily supplement in a convenient 90-capsule bottle.

## Description

THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules : desertcart.ae: Automotive

Review: Excellent product for MTHFR genetic disorder
Review: I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

## Features

- Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
- Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health
- Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
- Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B00O5AHC4S |
| ASIN  | B00O5AHC4S |
| Age Range Description | Adult |
| Best Sellers Rank | #3,209 in Health ( See Top 100 in Health ) #69 in Multivitamins Nutritional Supplements |
| Brand | THORNE |
| Customer Reviews | 4.7 4.7 out of 5 stars (2,654) |
| Customer reviews | 4.7 4.7 out of 5 stars (2,654) |
| Date First Available | 20 November 2012 |
| Format | Capsule |
| Is Discontinued By Manufacturer  | No |
| Item model number  | No Model |
| Manufacturer  | Thorne Research |
| Product Dimensions  | 6.05 x 6.05 x 10.74 cm; 108.86 g |
| Units | 2 Count |
| Weight | 0.24 Pounds |

## Product Details

- **Brand:** THORNE
- **Diet type:** Gluten Free
- **Flavour:** Unflavored
- **Item form:** Capsule
- **Primary supplement type:** Riboflavin

## Images

![Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6, and B12 - Supports methylation and healthy level of homocysteine - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules - Image 1](https://m.media-amazon.com/images/I/61BtsSBpN9L.jpg)

## Available Options

This product comes in different **Style** options.

## Questions & Answers

**Q: What is the difference between "methyl-guard" and "methyl-guard plus" products?**
A: Methyl Guard plus is stronger.  The Methyl Guard Plus contains about twice as much b12 (3mg vs 1.2mg), about twice as much folate (3mg vs 1.2mg), about twice as much b6 (45mg vs 20.4mg) and contains Riboflavin.

**Q: Why doesn't it show the label, I'm not going to pay this amount for something without knowing what and how much is in it!**
A: If you look at the selection of pictures to right of the bottle the bottom picture includes the label.  You can click on that image to show it larger.

**Q: are these capsules enteric coated? taking pyridoxal-5-phosphate without enteric coating useless**
A: Not coated. Just a vegetarian capsule. For me, my body has been starved of these active forms of B vitamins that it's anything but useless. If you want to encourage it not to digest as quickly, a trick my doctor tells me to do (with fish oil for example) is to freeze the capsule so that it takes longer to digest. You can look for the specific forms of active B vitamins to find them enteric coated. Details on the product: https://www.thorne.com/products/dp/methyl-guard-plus-reg

**Q: Does this turn your stools orange colored?**
A: Orange stools may signify you are dumping copper. Look up un bound copper, bioavailable copper and copper toxicity. You need boron and vit K2.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Review
*by C***Y on 11 September 2025*

Excellent product for MTHFR genetic disorder

### ⭐⭐⭐⭐⭐ Review
*by A***L on 4 August 2025*

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

### ⭐⭐⭐⭐⭐ Review
*by M***C on 2 February 2026*

Great product, contains Betaine?TMG too which is essential for proper maintenance of homocysteine levels.

## Frequently Bought Together

- THORNE Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine* - Gluten, Dairy & Soy-Free - 90 Capsules
- THORNE Magnesium CitraMate - Magnesium Supplement with Citrate-Malate - Support Heart, Skeletal Muscles, Cardiac, Lung Function, and Bone Density* - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
- THORNE Vitamin D-5000 - Vitamin D3 Supplement - Support Healthy Bones, Teeth, Muscles, Cardiovascular, and Immune Function* - NSF Certified for Sport - Dairy-Free, Soy-Free - 60 Capsules

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-03-18*