--- product_id: 110749629 title: "FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 8 Treatments" brand: "frontline" price: "$172.13" currency: USD in_stock: true reviews_count: 9 category: "Frontline" url: https://www.desertcart.us/products/110749629-frontline-plus-flea-and-tick-treatment-for-medium-dogs-up store_origin: US region: United States of America --- # 30-day protection waterproof formula kills fleas & ticks FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 8 Treatments **Brand:** frontline **Price:** $172.13 **Availability:** ✅ In Stock ## Summary > 🛡️ Protect your pup like a pro—because your dog deserves the best defense! ## Quick Answers - **What is this?** FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 8 Treatments by frontline - **How much does it cost?** $172.13 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/110749629-frontline-plus-flea-and-tick-treatment-for-medium-dogs-up) ## Best For - frontline enthusiasts ## Why This Product - Trusted frontline brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Month-Long Defense:** One easy monthly dose shields your dog for a full 30 days—never worry about reapplying mid-month. - • **Waterproof & Active:** Waterproof topical formula stays effective even after baths or rainy walks—protection that won’t wash away. - • **Complete Pest Control:** Kills adult fleas, eggs, larvae, chewing lice, and ticks that carry Lyme disease—break the infestation cycle fast. - • **Trusted for 20+ Years:** Veteran pet owners rely on FRONTLINE Plus for proven, safe flea and tick protection since 2003. - • **Effortless Application:** Single-point application covers your dog’s entire body via sebaceous glands—easy, mess-free, and stress-free. ## Overview FRONTLINE Plus Flea and Tick Treatment for Medium Dogs (23-44 lbs) delivers fast-acting, waterproof protection that kills fleas, flea eggs, larvae, chewing lice, and ticks for a full 30 days with just one monthly topical dose. Trusted by pet owners for over 20 years, its dual active ingredients (fipronil and (S)-methoprene) break the flea life cycle while providing safe, easy application suitable for puppies 8 weeks and older. Keep your dog pest-free and protected year-round with this veterinarian-recommended solution. ## Description Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention. Review: Gets rid of pests - FRONTLINE Plus has been very effective at keeping fleas and ticks under control. It’s easy to apply, doesn’t have a strong odor, and hasn’t caused any irritation. I like that it provides long lasting protection with just one monthly dose. This has been a reliable product for us and definitely worth the purchase. Your pets will be happy you bought it. Review: Great product and service. - We loved this product. We were on the automatic ship plan and that was nice. We would recommend this dealer to anyone. We stopped because our dog was hit by a car. ## Features - Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease - Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control - Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days - FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products - Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations - Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B07NGRSVLF | | ASIN | B07NGRSVLF | | Active Ingredients | fipronil and (S)-methoprene | | Age Range Description | All Life Stages | | Allergen Information | Gluten Free | | Best Sellers Rank | #299 in Pet Supplies ( See Top 100 in Pet Supplies ) #6 in Dog Flea Drops | | Brand Name | Frontline | | Customer Reviews | 4.4 4.4 out of 5 stars (23,817) | | Date First Available | February 7, 2019 | | Dog Breed Size | Medium | | Included Components | Applicator | | Item Form | Liquid | | Item Type Name | Flea and Tick Treatment for Dogs Medium Dogs | | Item model number | 72218 | | Manufacturer | Boehringer Ingelheim Animal Health | | Manufacturer | Boehringer Ingelheim Animal Health | | Manufacturer Part Number | 65331-5 | | Manufacturer recommended age | 1 month and up | | Model Number | 72218 | | Product Dimensions | 0.63 x 5.75 x 4.5 inches; 2.08 ounces | | Scent Name | Unscented | | Target Species | Medium Dog, 23-44 Pounds | | UPC | 611030624557 350604062455 | | Unit Count | 8 Count | | Volume | 6 Milliliters | | Warranty Description | If you are not satisfied with Frontline Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842. | ## Product Details - **Active Ingredients:** fipronil and (S)-methoprene - **Age Range (Description):** All Life Stages - **Allergen Information:** Gluten Free - **Brand:** Frontline - **Dog Breed Size:** Medium - **Item Form:** Liquid - **Item Volume:** 6 Milliliters - **Scent:** Unscented - **UPC:** 611030624557 350604062455 ## Images ![FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 8 Treatments - Image 1](https://m.media-amazon.com/images/I/71RF+BUay0L.jpg) ## Available Options This product comes in different **Size** options. ## Questions & Answers **Q: shelf life?** A: according to Frontline's website FAQ question #7 states: FRONTLINE Brand Products do not carry an expiration date. We recommend storing FRONTLINE Brand Products at room temperature and keeping them sealed in their original packaging. If stored under these conditions, FRONTINE Brand Products will not expire. **Q: If my dog is 22 do I buy up to 22 or go to the second category 23 up?** A: I am in the same situation. I have found that the smaller dose is not effective. But the 23 and up does the trick. **Q: Is this Waterproof** A: Yes, but the product must dry before a bath or swimming. “Waterproof” is also listed on the front of package. **Q: Does it actually work ?** A: We've used this product in the past and it worked, and we live on a corner and have our dogs in the country and camping in wooded areas. If I remember correctly, it won't kill adult fleas, but prevents them from reproducing and I believe the nuts as well. If there's an infestation, or a source of fleas nearby, even a neighbor animal, that doesn't have the flea problem addressed, the flea cycle will continue. ## Customer Reviews ### ⭐⭐⭐⭐⭐ Gets rid of pests *by B***T on January 18, 2026* FRONTLINE Plus has been very effective at keeping fleas and ticks under control. It’s easy to apply, doesn’t have a strong odor, and hasn’t caused any irritation. I like that it provides long lasting protection with just one monthly dose. This has been a reliable product for us and definitely worth the purchase. Your pets will be happy you bought it. ### ⭐⭐⭐⭐⭐ Great product and service. *by M***R on March 8, 2026* We loved this product. We were on the automatic ship plan and that was nice. We would recommend this dealer to anyone. We stopped because our dog was hit by a car. ### ⭐⭐⭐⭐⭐ Excellent product, BUT... *by B***A on December 17, 2008* This is an excleent product, but it is not a miracle worker. In other words, you need to use the stuff properly. (1) this product is water resistant...not soap resistant. So if you use this stuff then go and use some of that heavily perfumes soapy shampoo that msot people use..then you are washign it right off. (2) if you chose to bathe your dog..bathe him/her first then wait 2-3 days THEN apply the product so that it will be distrubited properly. (3) Remember that if you have a heavy flea problem that you need to treat the pet and the environment. You can't jsut put it on the dog and not get rid of the fleas in your house, car, yard, etc.. Yeah it will kill the fleas on him/her, but they will get reinfested with fleas everytime they go back into the flea filled environment. This is the only product that I use for my dog. Of you purchase ANYTHING over the counter (biospot, hartz ::shudders::, etc) then you are wasting your money. Flea dips work, but they only kill the fleas that are on the dog when you bathe him/her. Frontline PLUS is great becasue it keeps killing for up to a month. Also, Frontline Plus has a better range of killing fleas than plain ole' Frontline. The "PLUS" means that it kills larvae and eggs and so much more than adult fleas. IF USED CORRECTLY and ROUTINELY this is an EXCELLENT product!!! I highly recommend it. This product also kills ticks. ## Frequently Bought Together - Frontline Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs. 8 Treatments - FRONTLINE Plus for Dogs Flea and Tick Treatment (Small Dog, 5-22 lbs.) 8 Doses (Orange Box) - Frontline Plus Flea and Tick Treatment for X-Large Dogs Up to 89 to 132 lbs. 8 Treatments --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.us/products/110749629-frontline-plus-flea-and-tick-treatment-for-medium-dogs-up](https://www.desertcart.us/products/110749629-frontline-plus-flea-and-tick-treatment-for-medium-dogs-up) --- *Product available on Desertcart United States of America* *Store origin: US* *Last updated: 2026-04-22*