---
product_id: 101984272
title: "- Acne Retinoid Treatment Gel, 0.1% Adapalene, 15g Tube | Over-The-Counter Retinoid, Clears Acne And Prevents Breakouts, Gentle For Sensitive Skin, 30-Day Supply, 15G Tube"
brand: "differin"
price: "$23.37"
currency: USD
in_stock: true
reviews_count: 8
url: https://www.desertcart.us/products/101984272-acne-retinoid-treatment-gel-0-1-adapalene-15g-tube-over
store_origin: US
region: United States of America
---

# 0.1% Adapalene Rx-strength retinoid Up to 87% acne reduction in 12 weeks Works deep in pores within 5 minutes - Acne Retinoid Treatment Gel, 0.1% Adapalene, 15g Tube | Over-The-Counter Retinoid, Clears Acne And Prevents Breakouts, Gentle For Sensitive Skin, 30-Day Supply, 15G Tube

**Brand:** differin
**Price:** $23.37
**Availability:** ✅ In Stock

## Summary

> ✨ Clear skin, no compromises—your glow-up starts now!

## Quick Answers

- **What is this?** - Acne Retinoid Treatment Gel, 0.1% Adapalene, 15g Tube | Over-The-Counter Retinoid, Clears Acne And Prevents Breakouts, Gentle For Sensitive Skin, 30-Day Supply, 15G Tube by differin
- **How much does it cost?** $23.37 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.us](https://www.desertcart.us/products/101984272-acne-retinoid-treatment-gel-0-1-adapalene-15g-tube-over)

## Best For

- differin enthusiasts

## Why This Product

- Trusted differin brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Deep Pore Power:** Targets acne at the root for lasting clarity
- • **Gentle Yet Potent:** Oil-free, fragrance-free, and dermatologist recommended for sensitive skin
- • **Fast-Acting Formula:** Penetrates pores in just 5 minutes—because time is skin
- • **Clinically Proven Results:** Up to 87% fewer breakouts in 12 weeks—real results, no guesswork
- • **Prescription Strength, No Rx Needed:** Adapalene retinoid delivers Rx-level acne defense over the counter

## Overview

Differin Acne Retinoid Treatment Gel features 0.1% adapalene, a prescription-strength retinoid that penetrates deep into pores within 5 minutes to clear and prevent acne. Clinically proven to reduce breakouts by up to 87% in 12 weeks, this dermatologist-recommended, oil-free, fragrance-free gel is designed for sensitive, acne-prone skin and can be seamlessly integrated into your daily skincare routine without a prescription.

## Description

Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin's overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).

## Features

- TARGETS ACNE: Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
- CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
- RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
- DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
- REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use

## Technical Specifications

| Specification | Value |
|---------------|-------|
| Asin | B07L1PHSY9 |
| Best Sellers Rank | #1 in Facial Skin Care Sets & Kits |
| Department | Beauty & Personal Care |
| Item Model Number | 0299.492030 |
| Manufacturer | Galderma Laboratories, Inc |
| Product Dimensions | 1.5 x 2.1 x 6.5 inches; 1.25 ounces |
| Upc | 302994920303 302994910151 |

## Product Details

- **Brand:** Differin
- **Item Form:** Gel
- **Product Benefits:** Anti-Acne
- **Scent:** Unscented
- **Skin Type:** Acne Prone, Sensitive

## Images

![- Acne Retinoid Treatment Gel, 0.1% Adapalene, 15g Tube | Over-The-Counter Retinoid, Clears Acne And Prevents Breakouts, Gentle For Sensitive Skin, 30-Day Supply, 15G Tube - Image 1](https://m.media-amazon.com/images/I/71hRgEJ33nL.jpg)

## Available Options

This product comes in different **Size, Style** options.

## Questions & Answers

**Q: How long does it take to see results when using Differin Gel?**
A: Differin Gel is formulated with Adapalene Retinoid, which works deep into pores in 5 minutes. When consistently applied to the full face, you may start to see results in as little as 1 week with best results after 12 weeks.

**Q: Can I use Differin Gel if I have sensitive skin?**
A: Differin Gel includes Adapalene an ingredient shown to have improved tolerability resulting in less redness and skin irritation. Apply once daily to dry skin after cleansing. Stop use and consult a dermatologist if irritation becomes severe.

**Q: How often should I apply Differin Gel each day?**
A: Use once daily (AM or PM). Clean skin gently and pat dry before applying. Cover the entire face with a thin layer. Do not use more than once a day. Applying more than directed will not provide faster or better results and may worsen skin irritation.

**Q: Can I use moisturizer with Differin Gel?**
A: Moisturizing is essential in supporting the skin barrier when using Differin Gel and can help to combat excessive dryness or irritation. Apply Differin Gel to clean, dry skin then follow with non-comedogenic moisturizer and SPF in the AM.

**Q: Does Differin Gel cause purging or make acne worse before it gets better?**
A: Acne may appear to worsen within the first few weeks of use as Differin Gel accelerates skin cell turnover. Continue treatment as directed; symptoms should subside between weeks 2-4. If severe irritation occurs stop use and consult dermatologist.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Patience can make a difference
*by  on Reviewed in the United States August 30, 2019*

Background on my skin:I have combination oily skin. I am pretty sensitive to things, especially due to eczema. I also have hormonal problems (which I am taking pills for) to add to that. So, I typically would get the big, hurtful, annoying, last for like ever cyst acne more so than the other kinds of acne. Because of my hormones, they most often were located on my chin. I use Clinique for my facial skin needs but more recently I had been having problems controlling the cystic acne, especially on the chin region. My friend started Differin a few weeks prior and said that I should try it/look into it. I read up on it and decided to give it a try.Here are my findings:1. I was not allergic to Differin. That's a big plus. Sometimes my skin can be weird and it takes a few weeks before my skin decides that this is a bad thing and rebels. I am about 3.5 months into Differin and I have not had a reaction. (An allergic reaction for me is like getting a really itchy sunburn. It also takes forever to get back to normal.)2. This is not a quick fix. Consider it a lifestyle change. You will need to be consistent and I would suggest using it for at least 3 months before moving on. From what I read, this is because your skin is relearning and this takes time.3. You will most likely have a purging period and it really sucks. My purging period happened around week 4. You will get more acne than before. Yes, it really sucked and hurt because they were still cystic acne. However, you might begin to notice cystic acne does not last as long.4. This is not a cure for acne. You are not going to magically never get a pimple again in your life with this. It will, however, help make them smaller and heal a lot faster.5. This may be very drying for some people and you may have to change your routine up a bit. Some people found it better to apply their moisturizer (to clean skin) prior to using Differin - like my friend. I have oily skin so I did not. Find a routine that works. If you are using moisturizer and are still drying out, try cutting back the Differin at first. Then slowly add it in until you can use every day or every other.6. This should go without saying but...if you go outside, use a sunscreen. Differin can make you more sensitive to the sun. My other skin products already had the warning so I didn't need to worry about changing this to my routine.7. Use only once per day. I do so at night.8. One tube should last between 2-3 months, depending on the size of your face. You really only need a pea-size portion. Do not overuse and do not spot treatment.So, about 3.5 months in, I have definitely noticed a major change for the good. I have cut all other acne products (minus the little bit in my foundation which I plan on stopping when I finish my supply. Wish me luck on that!) I still get random pimples but they don't last long and thankfully, my chin does not look like bubblewrap hidden under makeup anymore.In summary:I would definitely recommend this product but suggest to be careful. Watch what you are using with it. You might have to change your skin regime. Use moisturizer and sunscreen. Take a breath and get through the purging phase. Obviously, do not continue to use the product if you are allergic. Have patience! It might really be worth it.Good luck to everyone out there. You're not alone!

### ⭐⭐⭐⭐⭐ It works if you're patient!
*by  on Reviewed in the United States June 9, 2018*

I have been using Differin for over a year now (around 14 months giver or take) and did not publish a review until now. If you want an in-depth review, read on. For the tl;dr version: it works, just stick with it. Btw, I was not paid for this nor was I sent this product (although they should be sending it, given how many tubes I've bought).I had the MOST TERRIBLE acne. No, I'm not talking about a small tiny excuse of a blemish that your friend with great skin complains about when she has her "bad skin" days. My face was RED and PAINFUL. My cheeks were COVERED all the time, and I had no area on my face where acne wouldn't pop up. Nose, brows, chin, jaw, underneath the jaw, you name it. I had tried Curology and while my skin got amazing for the first 6 months, my acne returned with a VENGEANCE. I had tried so many things, clay masks, benzoyl peroxide, salicylic acid, other AHAs and BHAs, sulfur, rosehip oil, and even supplements like zinc and milk thistle, you name it. Nothing worked at all. I was so so embarrassed of my skin, but I couldn't wear makeup either since makeup made my acne SO MUCH worse.I heard about Differin and I figured "well, might as well give this a try cause it can't get any worse". Boy, I was wrong. It did get worse. Much worse. Suddenly I had SO much more acne and I felt like crap. I couldn't believe my skin could get worse, but it did. Differin was the only thing I was using so I knew this was it. I was depressed but I stuck with it, cause I wanted to test it for at least 4 months. I thought I might as well test the claim, since my skin is so bad already.The first month was really really bad. It brought all underlying acne to the surface i.e. the purge phase. It did the purging for 3-4 months, but the first month was THE WORST. Not gonna lie to you, that first month will probably be the worst skin you've had in your life. Your skin will become SO SENSITIVE! Anticipate that! My skin has never been sensitive to products but while using this, my regular moisturizers and masks would sting like crazy (get stuff with no fragrance/alcohol or acids!). It didn't affect my skin in any other way, it just stung a lot. Oh, and I used to get my upper lip and brows waxed. Not with this you can't, the wax will tear off your skin since it gets much more sensitive. I learned the hard way. ONLY do threading!However, after I waited out the terrible, terrible first month, I slowly began to see improvements. Marginal, though. I had acne, but I probably had just a tad less. And it continued that way, it kept improving. Eventually, my skin was so much clearer than before! I still had acne, mind you, it's not a miracle drug, but it was few and far in between. There would be times when I had no active acne, which was HUGE for me!! My face usually looked like a connect the dots game. However, I did hit a plateau. This worked phenomenally at reducing my ugly acne all over my face to a few zits here and there, however, my issue was deeper than that. Eventually, I went to a doctor and got on spironolactone.Now, I am both on my Spiro and this. The combo of these two have made my skin so clear! I could have never imagined this day! I still need to use this, I have noticed my Spiro is not enough to keep zits at bay and if I skip a couple of nights putting on differin, new zits come up. I am so much happier now that I don't have zillions of gross zits on my face. I still get zits if I eat sugar or near my period but man, I am a long way from before! I have a few blemishes left over from before but I honestly don't care, my skin looks wayyy better. I can hide my blemishes with a sheer foundation of spot concealing if I want.So if you've read till the end, the lesson is: be PATIENT and be realistic! Your acne did not appear overnight and will not disappear overnight. If you stick with this, it WILL work. However, your mileage may vary. My acne was extremely bad, so after I hit my "acne plateau" I went to the doctor. If your acne is not as bad, it's likely differin is all you need for clear skin! If you're on the fence, confused, depressed, frustrated and/or can't afford a doctor, it's worth a shot! Just be patient and gentle with your skin!

### ⭐⭐⭐⭐⭐ Game changer!
*by  on Reviewed in the United States August 6, 2026*

We purchased Differin for my teenage daughter’s acne after hearing so many dermatologists recommend adapalene, and it has absolutely earned a permanent place in her skincare routine.It’s important to know that this isn’t an overnight treatment. She experienced the typical “purging” phase during the first several weeks, but once we stayed consistent, we started seeing a noticeable improvement in both active breakouts and the overall texture of her skin. New blemishes became less frequent, and existing acne healed more quickly.A little goes a long way—a pea-sized amount is enough for the entire face. We use it only at night and make sure she wears moisturizer because it can be drying at first. Daily sunscreen is also a must since retinoids can make skin more sensitive to the sun.If you’re just starting Differin, my biggest advice is to introduce it slowly (a few nights a week at first) and be patient. The results are worth the wait. For anyone looking for an effective over-the-counter acne treatment backed by years of research, I would definitely recommend giving Differin a try.

## Frequently Bought Together

- Differin Acne Treatment Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May Vary)
- PanOxyl Acne Foaming Wash Benzoyl Peroxide 10% Maximum Strength Antimicrobial, 5.5 Oz
- Mighty Patch™ Original patch from Hero Cosmetics – The #1 Hydrocolloid Acne Pimple Patch for Shrinking Zits and Whiteheads in 1 use; Nighttime Spot Stickers for Face and Skin (36 Count)

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*Product available on Desertcart United States of America*
*Store origin: US*
*Last updated: 2026-08-31*